Mitochondrial function and substrate availability
Mitochondrial function and substrate availability
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DOI：
10.1097/01.ccm.0000278044.19217.73
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发表时间：
2007-09-01
影响因子：
8.8
通讯作者：
Leverve, Xavier M.
中科院分区：
文献类型：
--
作者：
Leverve, Xavier M.
碳水化合物和脂肪氧化通过不同的途径支持能量代谢，表现出相似和不同之处。脓毒症期间能量代谢的改变是公认的；然而，氧气或底物供应的失败并不是一个突出的原因。由脓毒症引起的“线粒体细胞病变”的发生解释了其中一些异常，这可能代表了“代谢冬眠”，这是疾病非常急性期的一种潜在防御策略。我们对线粒体新陈代谢参与细胞信号传递的看法有了很大的发展。由于呼吸链的结构，电子的提供方式(复合体1的上游或下游[即烟酰胺腺嘌呤二核苷酸[还原形式]或黄素腺嘌呤二核苷酸[还原形式])在几种功能的调节中起着重要作用，包括三磷酸腺苷的合成和活性氧的产生。此外，细胞内能量通道和区隔的现代观点可能会为细胞在病理状态下能量分布的变化打开吸引人的假说，例如脓毒症。(《危重医疗》2007；35[补充]：S454-S460)
Carbohydrates and lipid oxidations support energy metabolism by distinct pathways exhibiting similarities and differences. Alterations of energy metabolism during sepsis are well recognized; however, failure of oxygen or substrate supply is not a prominent cause. The occurrence of a "mitochondrial cytopathy" induced by sepsis explains some of these abnormalities, which may represent a "metabolic hibernation," a potential strategy of defense during the very acute phase of the illness. Our view of the involvement of mitochondrial metabolism in cell signaling has evolved considerably. Because of the structure of the respiratory chain, the way electrons are provided (upstream or downstream of complex 1 [i.e., nicotinamide adenine dinucleotide {reduced form} or flavin adenine dinucleotide {reduced form}]) plays an important role in the regulation of several functions, including the yield of adenosine triphosphate synthesis and the production of reactive oxygen species. Moreover, the modern view of energy channeling and compartmentation in the cell may open attractive hypotheses regarding the changes in cellular energy distribution in pathologic states, such as sepsis. (Crit Care Med 2007; 35[Suppl.]:S454-S460)