Shadows cast by retinal blood vessels mapped in primary visual cortex
Shadows cast by retinal blood vessels mapped in primary visual cortex
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DOI：
10.1126/science.1074887
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发表时间：
2002-10-18
期刊：
影响因子：
56.9
通讯作者：
Horton, JC
中科院分区：
文献类型：
--
作者：
Adams, DL;Horton, JC
哺乳动物的眼睛是一种非凡的光学装置，但其设计并不完美。供应视网膜内部的血管位于感光层的前面，阻挡光线的进入。它们的阴影在视野中形成了一种失明模式，与眼睛中最大血管的位置精确对应。我们在这里表明，在松鼠猴中，血管的局灶性剥夺导致眼睛膝皮质投影的重新布线，将视网膜血管树的图像印到初级视觉皮层上。这个过程生动地说明了神经元活动的局部不平衡会影响正常发育过程中的柱形成。
The mammalian eye is a remarkable optical device, but its design is not perfect. The blood vessels that supply the inner retina are located in front of the photoreceptor layer, blocking access to light. Their shadows create a pattern of blindness in the field of vision that corresponds precisely to the location of the largest vessels in the eye. We show here that in squirrel monkeys, focal deprivation by blood vessels leads to rewiring of the eye's geniculocortical projections, imprinting an image of the retinal vascular tree onto the primary visual cortex. This process illustrates vividly that local imbalances in neuronal activity can influence column formation during normal development.