Systematic Reviews and Meta- and Pooled Analyses Pelvic In ﬂ ammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies-猫眼课题宝

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2016

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Christina B. Rasmussen;S. Kjaer;V. Albieri;E. Bandera;J. Doherty;E. Høgdall;P. Webb;S. Jordan;M. Rossing;K. Wicklund;M. Goodman;F. Modugno;K. Moysich;R. Ness;R. Edwards;J. Schildkraut;A. Berchuck;S. Olson;L. Kiemeney;L. Massuger;S. Narod;C. Phelan;H. Anton-Culver;A. Ziogas;A. Wu;C. Pearce;H. Risch;A. Jensen

炎症与卵巢癌的发生有关。然而，研究盆腔炎性疾病（PID）和卵巢癌风险之间的关联很少，而且不一致。我们根据肿瘤的行为和组织类型研究了PID与上皮性卵巢癌风险之间的关系。我们汇总了1989年至2009年期间卵巢癌协会联盟（OCAC）进行的13项病例对照研究的数据，包括9，162名卵巢癌女性，2，354名交界性肿瘤女性和14，736名对照参与者。估计研究特异性比值比，随后使用随机效应模型将其合并为汇总比值比。PID病史与交界性肿瘤风险增加相关（合并比值比（pOR）= 1.32，95%置信区间（CI）：1.10，1.58）。至少有2次PID发作的女性发生交界性肿瘤的风险增加2倍（pOR = 2.14，95% CI：1.08，4.24）。未观察到PID与卵巢癌总体风险之间存在关联（pOR = 0.99，95% CI：0.83，1.19）;然而，观察到低级别浆液性肿瘤的风险无统计学显著性增加（pOR = 1.48，95% CI：0.92，2.38）。总之，PID与交界性卵巢肿瘤的风险增加有关，特别是在多次PID发作的女性中。虽然我们的研究结果表明PID与组织型特异性相关，但PID与卵巢癌风险的相关性仍然有些不确定，需要进一步研究。

In ﬂ ammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic in ﬂ ammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk of epithelial ovarian cancer according to tumor behavior and histotype. We pooled data from 13 case-control studies, conducted between 1989 and 2009, from the Ovarian Cancer Association Consortium (OCAC), including 9,162 women with ovarian cancers, 2,354 women with borderline tumors, and 14,736 control participants. Study-speci ﬁ c odds ratios were estimated and subsequently combined into a pooled odds ratio using a random-effects model. A history of PID was associated with an increased risk of borderline tumors (pooled odds ratio (pOR) = 1.32, 95% con ﬁ dence interval (CI): 1.10, 1.58). Women with at least 2 episodes of PID had a 2-fold increased risk of borderline tumors (pOR = 2.14, 95% CI: 1.08, 4.24). No association was observed between PID and ovarian cancer risk overall (pOR = 0.99, 95% CI: 0.83, 1.19); however, a statistically nonsigni ﬁ cantly increased risk of low-grade serous tumors (pOR = 1.48, 95% CI: 0.92, 2.38) was noted. In conclusion, PID was associated with an increased risk of borderline ovarian tumors, particularly among women who had had multiple episodes of PID. Although our results indicated a histotype-speci ﬁ c association with PID, the association of PID with ovarian cancer risk is still somewhat uncertain and requires further investigation.

Systematic Reviews and Meta- and Pooled Analyses Pelvic In ﬂ ammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies

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