Neutropenia in human immunodeficiency virus infection - Data from the Women's Interagency HIV Study
Neutropenia in human immunodeficiency virus infection - Data from the Women's Interagency HIV Study
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DOI：
10.1001/.405
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发表时间：
2006-02-27
影响因子：
--
通讯作者：
Watts, DH
中科院分区：
文献类型：
--
作者：
Levine, AM;Karim, R;Watts, DH
背景：中性粒细胞减少症在感染人类免疫缺陷病毒(HIV)的个体中有很好的描述，大约10%到50%的病例会发生。高效抗逆转录病毒治疗(HAART)对中性粒细胞计数的影响和中性粒细胞减少对生存的意义之前都没有被评估过。方法：作为女性机构间HIV研究的一部分，评估了1729名感染HIV的妇女中中性粒细胞减少的患病率。结果：中性粒细胞减少症在HIV感染者中普遍存在；基线时，44%的患者中性粒细胞计数低于2 000个/亩L，7%的患者中性粒细胞计数低于1 000个/亩L；在7.5年的随访中，79%的患者中性粒细胞计数低于2000个/亩L，31%的患者中性粒细胞绝对计数低于1000个/亩L。HIV疾病参数恶化，如CD4细胞计数降低(P
Background: Neutropenia is well described in individuals infected with human immunodeficiency virus (HIV) and occurs in approximately 10% to 50% of cases. Neither the effect of highly active antiretroviral therapy ( HAART) on neutrophil counts nor the significance of neutropenia in terms of survival has previously been evaluated.Methods: The prevalence of neutropenia among 1729 HIV-infected women, followed up as part of the Women's Interagency HIV Study, was evaluated. The CD4 lymphocyte counts, HIV-1 RNA levels, and complete blood cell counts, including absolute neutrophil counts, were obtained at 6-month intervals.Results: Neutropenia was common among HIV-infected women; at baseline, 44% had neutrophil counts less than 2000/mu L, whereas 7% had counts less than 1000/ mu L. During 7.5 years of follow-up, neutrophil counts less than 2000/ mu L occurred on at least 1 occasion in 79%, whereas absolute neutrophil counts less than 1000/ mu L were documented in 31%. Worsening HIV disease parameters, such as lower CD4 cell counts ( P