Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: results from a high-risk community sample
Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: results from a high-risk community sample
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DOI：
10.1016/j.biopsych.2006.05.025
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发表时间：
2007-01-01
影响因子：
10.6
通讯作者：
Schmidt, Martin H.
中科院分区：
文献类型：
--
作者：
Laucht, Manfred;Becker, Katja;Schmidt, Martin H.
背景：以前的研究表明，人格特质，特别是新奇寻求（NS），增加药物滥用的风险。解释这种关联的一个可能的解释与共同的遗传因素有关。本研究的目的是检查多巴胺D4受体基因（DRD4）的等位基因变体是否与青少年的酒精使用相关，并确定NS介导这些联系的程度。303名青少年（144名男性参与者，159名女性参与者，约15岁）完成自我报告问卷测量酒精摄入量和气质（青少年气质和性格量表[JTCI]）。DNA分型DRD4外显子III多态性。携带DRD4 7重复等位基因的男性参与者每次饮酒的最大量更高，并且与没有该等位基因的男性参与者相比，终生重度饮酒率更高。在两种性别中，较高水平的NS与较高的酒精摄入量相关。多元回归分析支持NS的作用，在调解DRD4和大量饮酒之间的关系，在男性青少年，但不是在女性adolescents.Conclusions：这些研究结果扩展了以前的工作突出的意义，人格特质作为一个中介因素之间的遗传易感性和物质使用的早期实验使用期间。
Background: Previous research suggests that personality traits, particularly novelty seeking (NS), increase the risk of substance abuse. One possible explanation to account for this association relates to common genetic factors. The aim of this study was to examine whether allelic variants of the dopamine D4 receptor gene (DRD4) are associated with alcohol use in adolescents and to determine the extent to which these links are mediated by NS.Methods: Three hundred three adolescents (144 male participants, 159,female participants, approximately 15 years old) from a high-risk community sample completed self-report questionnaires measuring alcohol intake and temperament (Junior Temperament and Character inventory [JTCI]). DNA was genotyped for the DRD4 exon III polymorphism.Results. Male participants carrying the 7-repeat allele of DRD4 drank higher maximum amounts of alcohol per occasion and had greater lifetime rates of heavy drinking than male participants without this allele. Higher levels of NS were associated with higher alcohol intake in both genders. Multiple regression analyses support the role of NS in mediating the relationship between DRD4 and heavy drinking in male adolescents but not in female adolescents.Conclusions: These findings extend previous work highlighting the significance of personality traits as a mediating factor between genetic susceptibility and substance use during the period of early experimental use.