Wound healing in the bone chamber 1. Neoosteogenesis during transition from the repair to the regenerative phase in the rabbit tibial cortex.
Wound healing in the bone chamber 1. Neoosteogenesis during transition from the repair to the regenerative phase in the rabbit tibial cortex.
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骨腔中的伤口愈合 1. 兔胫骨皮质从修复阶段过渡到再生阶段期间的新骨生成。
DOI：
10.1002/jor.1100060409
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Albrektsson,T
中科院分区：
文献类型：
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作者：
Winet,H;Albrektsson,T
光学骨室技术，包括活体显微镜进行了描述，然后应用于测量原发性伤口愈合新生骨在兔胫骨皮质骨的期间，当纤维血管组织被再生骨血管组织取代。抽样的兔子数量很少，只能得出初步结论。定量测量是组织形态计量学的直接形式，用于确定观察结果的一致性，并假设骨腔缝隙愈合遵循其他研究确定为“特征”的原发性骨再生模式。结果支持这一假设，并表明骨长入开始于术后第3周（W3），骨前缘的最大线性生长速率为85.5 μm/天。还获得了W 6重塑的证据。虽然用于组织向内生长的骨腔环境是人造的，但它可以生成定量数据，这些数据可以为模拟与骨伤口愈合相关的病理生理过程提供统计学上有效的基础。
The optical bone chamber technique that includes intravital microscopy is described and is then applied to measuring primary wound healing neoostogenesis in rabbit tibia cortical bone during the period when fibrovascular tissue is being replaced by regenerating osteovascular tissue. The small population of rabbits sampled allowed only tentative conclusions. The quantitative measurements, a direct form of histomorphometry, are applied to determine the consistency of observations, with the hypothesis that healing into the bone chamber slit‐gap follows the pattern of primary bone regeneration established as “characteristic” by other studies. The results supported the hypothesis and showed that bony ingrowth started during the third postoperative‐week (W3) with a maximum linear growth rate of 85.5 μm/day for a bone front. Evidence for remodeling by W6 was also obtained. While the bone chamber environment for tissue ingrowth is artificial, it can generate quantitative data that may provide a statistically valid basis for modeling pathophysiologic processes associated with bone wound healing.