Retinoids: potential in cancer prevention and therapy
Retinoids: potential in cancer prevention and therapy
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DOI：
10.1017/s1462399404008488
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发表时间：
2004-11-30
影响因子：
6.2
通讯作者：
Gronemeyer, Hinrich
中科院分区：
文献类型：
--
作者：
Clarke, Nicole;Germain, Pierre;Gronemeyer, Hinrich
类维生素A（维生素A的衍生物）是在细胞生长、分化和死亡中起重要作用的信号分子。类维生素A通过两种类型的受体起作用-视黄酸受体（RAR α、RAR β和RAR γ）和类维生素A X受体（RXR α、RXR β和RXR γ）-其本身作为配体依赖性转录因子起作用。类维生素A由于其抗增殖和预防癌症的特性而在癌症研究中特别感兴趣。它们已被成功地用于治疗急性早幼粒细胞白血病（APL），并可抑制多种组织类型（如：G.皮肤癌、肺癌、乳腺癌和口腔癌）。广泛的研究工作一直致力于阐明类维生素A诱导的分子和细胞网络，最近这对类维生素A如何预防和对抗癌症产生了新的见解。
Retinoids (derivatives of vitamin A) are signalling molecules that play important roles in cell growth, differentiation and death. Retinoids act through two types of receptors - retinoic acid receptors (RAR alpha, RAR beta and RAR gamma) and retinoid X receptors (RXR alpha, RXR beta and RXR gamma) - which themselves act as ligand-dependent transcription factors. Retinoids are of special interest in cancer research owing to their antiproliferative and cancer-preventative properties. They have been used successfully to cure acute promyelocytic leukaemia (APL) and can suppress carcinogenesis in a variety of tissue types (e. g. skin, lung, breast and oral cancers). Extensive research efforts have been dedicated to elucidating the molecular and cellular networks that are induced by retinoids, and this has recently yielded novel insights into how retinoids can both prevent and combat cancer.