The development of a chromatography-free Mitsunobu reaction: Synthesis and applications of an anthracene-tagged phosphine reagent
The development of a chromatography-free Mitsunobu reaction: Synthesis and applications of an anthracene-tagged phosphine reagent
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DOI：
10.1021/cc030028h
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发表时间：
2003-09-01
影响因子：
--
通讯作者：
Parlow, JJ
中科院分区：
文献类型：
--
作者：
Lan, P;Porco, JA;Parlow, JJ
A general method for a polymer-assisted solution-phase (PASP) Mitsunobu reaction using a combination of anthracene-tagged phosphine and polymer-supported azodicarboxylate is reported. The anthracene-tagged phosphine allows for the removal of phosphine/phosphine oxide by sequestration through a chemoselective Diels-Alder reaction with a maleimide resin. The polymer-bound azodicarboxylate facilitates the removal of excess alcohol, reagent, and byproducts by simple filtration. The final pure products are obtained after a simple filtration and concentration.
