PDMS absorption of small molecules and consequences in microfluidic applications
PDMS absorption of small molecules and consequences in microfluidic applications
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DOI：
10.1039/b612140c
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发表时间：
2006-12-01
期刊：
影响因子：
6.1
通讯作者：
Beebe, David J.
中科院分区：
文献类型：
--
作者：
Toepke, Michael W.;Beebe, David J.
由聚二甲基硅氧烷（PDMS）制成的微流体装置具有许多可用于细胞培养应用的物理性质，例如透明度和透气性。PDMS的另一个显著特征是其吸收疏水小分子的能力。将分子分配到PDMS中可以显着改变溶液浓度，并可能改变实验结果。在这里，我们讨论了PDMS的吸收及其对微流体实验的潜在影响。
Microfluidic devices made out of polydimethylsiloxane (PDMS) have many physical properties that are useful for cell culture applications, such as transparency and gas permeability. Another distinct characteristic of PDMS is its ability to absorb hydrophobic small molecules. Partitioning of molecules into PDMS can significantly change solution concentrations and could potentially alter experimental outcomes. Herein we discuss PDMS absorption and its potential impact on microfluidic experiments.