Plastic Change in the Auditory Minimum Threshold Induced by Intercollicular Effects in Mice.
Plastic Change in the Auditory Minimum Threshold Induced by Intercollicular Effects in Mice.
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DOI：
10.1155/2016/4195391
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发表时间：
2016
影响因子：
3.1
通讯作者：
Chen QC
中科院分区：
文献类型：
--
作者：
Mei HX;Tang J;Fu ZY;Cheng L;Chen QC
在听觉通路中，下丘的连合连接了中脑背侧两侧的两个IC。这种互连可以在声音信号处理期间协调两个IC之间的交互。局灶电刺激30 m in引起的丘间效应可抑制或促进听觉反应，并引起IC神经元反应最低阈值(MT)的可塑性改变。MT的变化取决于最佳频率(BF)和MT差值。BF差值≤2 khz的IC神经元的MT移位大于BF差值>；2 khz的IC神经元。此外，向电刺激IC神经元移动的MTs随着两个IC之间MT差异的增大而增加。MT的变化持续一段时间，然后在~150 分钟内恢复到以前的水平。在交替刺激和记录条件下，两个ICs的丘脑相互作用或相互作用或单向作用。我们的结果提示，丘间效应可能参与了IC神经元MT的声学经验依赖性可塑性。
In the auditory pathway, the commissure of the inferior colliculus (IC) interconnects the two ICs on both sides of the dorsal midbrain. This interconnection could mediate an interaction between the two ICs during sound signal processing. The intercollicular effects evoked by focal electric stimulation for 30 min could inhibit or facilitate auditory responses and induce plastic changes in the response minimum threshold (MT) of IC neurons. Changes in MT are dependent on the best frequency (BF) and MT difference. The MT shift is larger in IC neurons with BF differences ≤2 kHz than in those with BF differences >2 kHz. Moreover, MTs that shift toward electrically stimulated IC neurons increase with the increasing MT difference between the two ICs. The shift in MT lasts for a certain period of time and then returns to previous levels within ~150 min. The collicular interactions are either reciprocal or unilateral under alternate stimulating and recording conditions in both ICs. Our results suggest that intercollicular effects may be involved in the acoustic experience-dependent plasticity of the MT of IC neurons.