Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates
Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates
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DOI：
10.1126/scitranslmed.aay4682
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发表时间：
2020-04-08
影响因子：
17.1
通讯作者：
Viventi, Jonathan
中科院分区：
文献类型：
--
作者：
Chiang, Chia-Han;Won, Sang Min;Viventi, Jonathan
持久、高分辨率、超薄且灵活的神经接口对于精确的大脑绘图和高性能神经假体系统至关重要。要对大脑大区域的数千个位点进行采样，需要集成供电电子设备，将许多电极多路连接到一些外部电线。然而，现有的多路复用电极阵列依赖于植入寿命有限的封装策略。在这里，我们开发了一种灵活的多路复用电极阵列，称为“神经矩阵”，它可以在啮齿动物和非人类灵长类动物中提供稳定的体内神经记录。神经矩阵持续一年多，并使用一千多个通道对厘米级的大脑区域进行采样。这里描述的持久封装（预计至少持续 6 年）、可扩展的设备设计和迭代体内优化是克服下一代神经技术当前面临的障碍的重要组成部分。
Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrode array, called "Neural Matrix," that provides stable in vivo neural recordings in rodents and nonhuman primates. Neural Matrix lasts over a year and samples a centimeter-scale brain region using over a thousand channels. The long-lasting encapsulation (projected to last at least 6 years), scalable device design, and iterative in vivo optimization described here are essential components to overcoming current hurdles facing next-generation neural technologies.