SGTx1, a Kv channel gating-modifier toxin, binds to the interfacial region of lipid bilayers.
SGTx1, a Kv channel gating-modifier toxin, binds to the interfacial region of lipid bilayers.
复制标题
SGTx1 是一种 Kv 通道门控修饰毒素，与脂质双层的界面区域结合。
DOI：
10.1529/biophysj.106.098681
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发表时间：
2007
影响因子：
3.4
通讯作者：
M. Sansom
中科院分区：
文献类型：
--
作者：
C. L. Wee;D. Bemporad;Z. Sands;D. Gavaghan;M. Sansom
SGTx1 is a gating-modifier toxin that has been shown to inhibit the voltage-gated potassium channel Kv2.1. SGTx1 is thought to bind to the S3b-S4a region of the voltage-sensor, and is believed to alter the energetics of gating. Gating-modifier toxins such as SGTx1 are of interest as they can be used to probe the structure and dynamics of their target channels. Although there are experimental data for SGTx1, its interaction with lipid bilayer membranes remains to be characterized. We performed atomistic and coarse-grained molecular dynamics simulations to study the interaction of SGTx1 with a POPC and a 3:1 POPE/POPG lipid bilayer membrane. We reveal the preferential partitioning of SGTx1 into the water/membrane interface of the bilayer. We also show that electrostatic interactions between the charged residues of SGTx1 and the lipid headgroups play an important role in stabilizing SGTx1 in a bilayer environment.
影响因子：
16.2
作者：
SWARTZ, KJ;MACKINNON, R
通讯作者：
MACKINNON, R
影响因子：
2.9
作者：
Ruta, V;MacKinnon, R
通讯作者：
MacKinnon, R