Microinjection of Cre Recombinase Protein Into Zygotes Enables Specific Deletion of Two Eukaryotic Selection Cassettes and Enhances the Expression of a DsRed2 Reporter Gene in Ccr2/Ccr5 Double-Deficient Mice
Microinjection of Cre Recombinase Protein Into Zygotes Enables Specific Deletion of Two Eukaryotic Selection Cassettes and Enhances the Expression of a DsRed2 Reporter Gene in Ccr2/Ccr5 Double-Deficient Mice
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DOI：
10.1002/dvg.20531
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发表时间：
2009-08-01
期刊：
影响因子：
1.5
通讯作者：
Mueller, Matthias
中科院分区：
文献类型：
--
作者：
Luckow, Bruno;Haenggli, Amy;Mueller, Matthias
趋化因子受体CCR2和CCR5代表了治疗重要炎症和感染性疾病（包括动脉粥样硬化和HIV感染）的潜在新治疗靶点。为了研究这两种受体在体内的功能，我们的目标是产生Ccr2/Ccr5双缺陷小鼠。因为这些基因是由
The chemokine receptors CCR2 and CCR5 represent potential novel therapeutic targets to treat important inflammatory and infectious diseases, including atherosclerosis and HIV infection. To study the functions of both receptors in vivo, we aimed to generate Ccr2/Ccr5 double-deficient mice. As these genes are separated by