Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.
Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.
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Mo1 大亚基（Mo1 α；以前的 gp 110）的亚细胞定位，Mo1 是一种与中性粒细胞粘附相关的表面糖蛋白。
DOI：
10.1172/jci111538
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Babior,BM
中科院分区：
文献类型：
--
作者：
Todd3rd,RF;Arnaout,MA;Rosin,RE;Crowley,CA;Peters,WA;Babior,BM
MO1α(原名GP 110)是一种中性粒细胞糖蛋白，其缺陷与多种中性粒细胞功能的异常有关，包括黏附、趋化和吞噬功能的缺陷。用免疫学和电泳法对整个细胞和亚细胞成分的检测表明，MO1α主要位于特定的颗粒中，但有一小部分存在于质膜中，在那里它暴露在细胞外环境中，并能与抗MO1抗体结合。在脱颗粒过程中，MO1α从特定的颗粒转移到质膜，导致这种糖蛋白的表面表达增加5-10倍。这些发现加上以前的工作表明，中性粒细胞和下表面之间的正常相互作用需要与质膜相关的MO1α，并增加了这样一种可能性，即释放出特定颗粒的中性粒细胞表面粘附性的增加可能部分是由于这些脱颗粒细胞的质膜中MO1α的数量增加。
Mo1 alpha (formerly gp 110) is a neutrophil glycoprotein whose deficiency is associated with abnormalities in several neutrophil functions, including defects in adherence, chemotaxis, and phagocytosis. Examination of whole cells and subcellular components by the use of both immunological and electrophoretic techniques demonstrated that Mo1 alpha was located primarily in the specific granules but that a small portion was present in the plasma membrane, where it is exposed to the extracellular environment and can bind to anti-Mo1 antibody. During degranulation, Mo1 alpha is translocated from the specific granules to the plasma membrane, resulting in a 5-10-fold increase in the surface expression of this glycoprotein. These findings plus previous work suggest that plasma membrane-associated Mo1 alpha is needed for a normal interaction between neutrophils and underlying surfaces, and raise the possibility that the increase in surface adhesiveness of neutrophils that have discharged their specific granules might be due in part to the increase in the amount of Mo1 alpha in the plasma membranes of these degranulated cells.Images