Centrally nucleated fibers (CNFs) compensate the fragility of myofibers in mdx mouse
Centrally nucleated fibers (CNFs) compensate the fragility of myofibers in mdx mouse
复制标题
DOI：
10.1097/00001756-199910190-00020
复制
发表时间：
1999-10-19
期刊：
影响因子：
1.7
通讯作者：
Yorifuji, H
中科院分区：
文献类型：
--
作者：
Narita, S;Yorifuji, H
中央有核纤维（CENTRALLY nucleated fibers，CNFs）是细胞质中央有核的肌纤维，被认为是再生肌纤维。它们通常在几种类型的肌营养不良症患者及其动物模型的组织病理学中观察到。在mdx小鼠（杜氏肌营养不良症的动物模型）中，CNF比非CNF对机械应力更具抗性，如伊文思蓝浸润所证明的。在肌营养不良症及其动物模型中，CNFs相对于肌肉中的群体，被认为是补偿肌肉组织的脆弱性的。(C)1999年利平科特威廉姆斯&威尔金斯。
CENTRALLY nucleated fibers (CNFs) are the myofibers which have nuclei in the center of cytoplasm, and are generally recognized as regenerated myobibers. They are commonly observed in the histopathology of the patients with several types of muscular dystrophies and their animal models. In the mdx mouse, an animal model of Duchenne muscular dystrophy, CNFs are more resistant than non-CNFs to mechanical stresses, as evidenced by the Evans blue infiltration. In relation to the population among muscles, CNFs are supposed to compensate the fragility of muscular tissue in muscular dystrophies and their animal models. (C) 1999 Lippincott Williams & Wilkins.