Improved postischemic recovery of cardiac pump function in exercised trained diabetic rats.
Improved postischemic recovery of cardiac pump function in exercised trained diabetic rats.
复制标题
改善运动训练的糖尿病大鼠的心脏泵功能的缺血后恢复。
DOI：
10.1152/jappl.1988.65.1.187
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Tow,JP
中科院分区：
文献类型：
--
作者：
Paulson,DJ;Kopp,SJ;Peace,DG;Tow,JP
本研究探讨糖尿病大鼠（链脲佐菌素，55 mg/kg）的运动训练是否会影响灌注心脏在缺血75分钟和再灌注30分钟后恢复泵功能的能力。所有心脏灌注缓冲液含有糖尿病血浆浓度的葡萄糖和游离脂肪酸。四组进行了研究：久坐不动的控制，训练的控制，久坐不动的糖尿病，和训练的糖尿病。训练对照组和糖尿病组大鼠在5%跑台上运动，21 m/min，90 min/d，6 d/wk，共8 wk。与两个对照组相比，久坐的糖尿病患者体重显著降低，血糖、三酰甘油和胆固醇升高。该组心脏在再灌注期间表现出泵功能的缺血后恢复抑制。与此相反，训练糖尿病大鼠表现出显着较低的血浆水平的三酰甘油和胆固醇相对于久坐不动的糖尿病患者。相对于久坐的糖尿病患者，训练的糖尿病大鼠心脏的缺血后心脏泵功能恢复得到改善。运动训练对对照组大鼠无影响。这些结果表明，运动训练对糖尿病大鼠产生了抗高血压作用，并提高了糖尿病心脏对缺血的耐受性。
This study examined whether exercise training of diabetic rats (streptozocin, 55 mg/kg) would affect the ability of perfused hearts to recover pump function after 75 min of ischemia and 30 min of reperfusion. All hearts were perfused with buffer containing the diabetic plasma concentrations of glucose and free fatty acids. Four groups were studied: sedentary control, trained control, sedentary diabetic, and trained diabetic. Trained control and diabetic rats were exercised on a treadmill at 5% grade, 21 m/min, 90 min/day, 6 days/wk for 8 wk. Sedentary diabetics had significantly lower body weight and elevated plasma glucose, triacylglycerol, and cholesterol relative to both control groups. Hearts from this group exhibited depressed postischemic recovery of pump function during reperfusion. In contrast, trained diabetic rats exhibited significantly lower plasma levels of triacylglycerol and cholesterol relative to sedentary diabetics. The postischemic recovery of cardiac pump function was improved in hearts from trained diabetic rats relative to sedentary diabetics. Exercise training had no effect on control rats. These results suggest that exercise training produces an antihyperlipidemic effect in diabetic rats and improves the tolerance of the diabetic heart to ischemia.