Low-Level CD4+ T Cell Activation in HIV-Exposed Seronegative Subjects: Influence of Gender and Condom Use
Low-Level CD4+ T Cell Activation in HIV-Exposed Seronegative Subjects: Influence of Gender and Condom Use
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DOI：
10.1086/651000
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发表时间：
2010-03-15
影响因子：
6.4
通讯作者：
Jennes, Wim
中科院分区：
文献类型：
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作者：
Camara, Makhtar;Dieye, Tandakha Ndiaye;Jennes, Wim
免疫激活被认为增加了对人类免疫缺陷病毒1型（HIV-1）传播的易感性，同时它被认为是建立有效的抗病毒免疫应答所必需的。在这项研究中，我们比较了暴露血清阴性（ESN）的合作伙伴之间的T细胞活化水平的HIV-1不一致的夫妇和艾滋病毒未暴露的控制对象在达喀尔，塞内加尔。ESN受试者的CD 4（+）T细胞上CD 38表达水平低于对照受试者。然而，这被发现与避孕套使用的并发差异有关：ESN受试者报告的避孕套使用程度高于对照组受试者，这与CD 38表达呈负相关。此外，我们观察到，与男性相比，女性的T细胞活化水平明显更高，与性行为无关。这些发现质疑了低水平CD 4（+）T细胞活化在抵抗HIV-1感染中的相关性，并强调在分析保护性免疫相关性时需要考虑高危人群的性别和性行为特征。
Immune activation has been suggested to increase susceptibility to human immunodeficiency virus type 1 (HIV-1) transmission, while at the same time it could be deemed essential for mounting an effective antiviral immune response. In this study, we compared levels of T cell activation between exposed seronegative (ESN) partners in HIV-1 discordant couples and HIV-unexposed control subjects in Dakar, Senegal. ESN subjects showed lower levels of CD38 expression on CD4(+) T cells than did control subjects. However, this was found to be associated with concurrent differences in the use of condoms: ESN subjects reported a higher degree of condom use than did control subjects, which correlated inversely with CD38 expression. In addition, we observed markedly higher levels of T cell activation in women compared with men, irrespective of sexual behavior. These findings question the relevance of low-level CD4(+) T cell activation in resistance to HIV-1 infection and underscore the need to take gender and sexual behavior characteristics of high-risk populations into account when analyzing correlates of protective immunity.