EEG signatures of auditory activity correlate with simultaneously recorded fMRI responses in humans
EEG signatures of auditory activity correlate with simultaneously recorded fMRI responses in humans
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DOI：
10.1016/j.neuroimage.2009.06.080
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Wise, Richard G.
中科院分区：
文献类型：
--
作者：
Mayhew, Stephen D.;Dirckx, Sharon G.;Wise, Richard G.
我们记录了同步，连续的功能磁共振成像过程中的诱发电位（AEPs），并确定了试验到试验的电生理反应，其特征在于在时域和时频域的幅度之间的相关性，和血液动力学BOLD响应。在3 T MRI扫描仪内记录来自30个EEG通道的皮质AEP，同时收集和不收集BOLD fMRI。以Cz（顶点）EEG反应为重点，从时域波形测量单次试验AEP反应。此外，一种新的方法被用来在时间-频率域（TF-ROI）的三个感兴趣的区域内的单次试验AEP响应。在fMRI扫描期间，N1和P2 AEP峰的潜伏期和振幅值与对照组相比无显著差异（p>0.16）。双侧次级听觉皮层、右侧中央前回、中央后回、前扣带皮层（ACC）和辅助运动皮层（SMC）均出现BOLD反应。通过逐体素分析观察到以下两项之间的显著单次试验相关性：（I）EEG TF-ROI 1（刺激后70-800 MS，1-5 Hz）的幅度和右侧初级（Heschl's gyrus）和次级（STG，颞平面）听觉皮层中的BOLD响应;以及（2）左侧中央前回和中央后回、ACC和SMC中的P2峰的幅度和BOLD响应。没有相关性，观察到单次试验NI振幅的体素的基础上。功能识别的听觉响应区域的fMRI-ROI分析确定了BOLD和EEG响应的进一步单次试验相关性。TF-ROI 1和TF-RO 12的TF幅度（刺激后20-400 ms，5-15 Hz）与所有研究的双侧听觉区（颞平面，上级颞回和Heschl's回）的BOLD反应显著相关。然而，N1和P2的峰值幅度，发生在类似的lavelength没有显示出相关性，在这些地区。双侧中央前回、中央后回和SMC的BOLD反应与N1和P2峰振幅相关。此外，P2和TF-ROI 1均与ACC相关。TF-ROI 3（刺激后400-900 ms）。4-10 Hz）的相关性仅在ACC和SMC中观察到。在整个组中，受试者平均N1峰值振幅与双侧初级和次级听觉皮层以及右侧中央前回和SMC中的BOLD反应振幅相关。我们证实，在连续和同步的功能磁共振成像中，可以记录到脑电诱发的脑电反应。我们已经提出了进一步的证据，经验单一的试验之间的耦合EEG和BOLD功能磁共振成像的反应，并表明，EEG信号的时间-频率分解可以产生额外的BOLD功能磁共振成像的相关性，主要是在听觉皮层，除了那些发现单独使用，诱发反应幅度。(C)2009爱思唯尔公司All rights reserved.
We recorded auditory-evoked potentials (AEPs) during simultaneous, continuous fMRI and identified trial-to-trial correlations between the amplitude of electrophysiological responses, characterised in the time domain and the time-frequency domain, and the hemodynamic BOLD response. Cortical AEPs were recorded from 30 EEG channels within the 3 T MRI scanner with and without the collection of simultaneous BOLD fMRI. Focussing on the Cz (vertex) EEG response, single-trial AEP responses were measured from time-domain waveforms. Furthermore, a novel method was used to characterise the single-trial AEP response within three regions of interest in the time-frequency domain (TF-ROIs). The latency and amplitude values of the N1 and P2 AEP peaks during fMRI scanning were not significantly different from the Control session (p>0.16). BOLD fMRI responses to the auditory Stimulation were observed in bilateral secondary auditory cortices as well as in the right precentral and postcentral gyri, anterior cingulate cortex (ACC) and supplementary motor cortex (SMC). Significant single-trial correlations were observed with a voxel-wise analysis, between (I) the magnitude of the EEG TF-ROI1 (70-800 MS post-stimulus, 1-5 Hz) and the BOLD response in right primary (Heschl's gyrus) and secondary (STG, planum temporale) auditory cortex; and (2) the amplitude of the P2 peak and the BOLD response in left pre- and postcentral gyri, the ACC and SMC. No correlation was observed with single-trial NI amplitude on a voxel-wise basis. An fMRI-ROI analysis of functionally-identified auditory responsive regions identified further single-trial correlations of BOLD and EEG responses. The TF amplitudes in TF-ROI1 and TF-RO12 (20-400 ms post-stimulus, 5-15 Hz) were significantly correlated with the BOLD response in all bilateral auditory areas investigated (planum temporale, superior temporal gyrus and Heschl's gyrus). However the N1 and P2 peak amplitudes, occurring at similar latencies did not show a correlation in these regions. N1 and P2 peak amplitude did correlate with the BOLD response in bilateral precentral and postcentral gyri and the SMC. Additionally P2 and TF-ROI1 both correlated with the ACC. TF-ROI3 (400-900 ms post-stimulus. 4-10 Hz) correlations were only observed in the ACC and SMC. Across the group, the subject-mean N1 peak amplitude correlated with the BOLD response amplitude in the primary and secondary auditory cortices bilaterally, as well as the right precentral gyrus and SMC. We confirm that auditory-evoked EEG responses can be recorded during continuous and simultaneous fMRI. We have presented further evidence of an empirical single-trial coupling between the EEG and BOLD fMRI responses, and show that a time-frequency decomposition of EEG signals can yield additional BOLD fMRI correlates, predominantly in auditory cortices, beyond those found using the, evoked response amplitude alone. (C) 2009 Elsevier Inc. All rights reserved.