Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia
Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia
复制标题
DOI：
10.1002/pbc.21147
复制
发表时间：
2008-03-01
影响因子：
3.2
通讯作者：
Stallings, Virginia A.
中科院分区：
文献类型：
--
作者：
Fung, Ellen B.;Kawchak, Deborah A.;Stallings, Virginia A.
镰状细胞性贫血（SCA）儿童骨量低，但骨转换尚未得到很好的描述。在这项研究中，生长和青春期发育进行了两次评估，间隔1年，在80个年轻的受试者与SS型SCA，而全身骨矿物质含量（BMC）和密度的测量在一个子集（n = 46）。在第二次访视时测量骨转换标志物。与健康儿童的已发表数据相比，骨形成（碱性磷酸酶）升高，而骨吸收（脱氧吡啶啉）降低。骨转换标志物与生长速度和青春期发育相关，但与骨量变化无关。
Children with sickle cell anemia (SCA) have low bone mass though bone turnover has not been well described. In this study, growth and pubertal development were assessed twice, 1 year apart, in 80 young subjects with type-SS SCA, while whole body bone mineral content (BMC) and density where measured in a subset (n = 46). Markers of bone turnover were measured at the second visit. Bone formation (alkaline phosphatase) was elevated, whereas bone resorption (deoxypryidinoline) was decreased compared to published data in healthy children. Markers of bone turnover correlated with growth velocity and pubertal development but not with changes in bone mass.