Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.
Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.
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DOI：
10.1073/pnas.2201355119
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发表时间：
2022-05-31
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
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作者：
这项研究讨论了大脑皮层在发育过程中是如何划分成专门区域的。虽然早期胚胎的图案和出生后的突触输入从丘脑感觉核是已知的关键，丘脑轴突的区域特异性调节皮质神经发生的早期作用知之甚少。我们通过开发一种遗传小鼠模型来研究这一点，在该模型中，丘脑皮质的投射在胚胎发育过程中未能正确形成，并发现这些轴突不仅需要增强浅层神经元的产生，而且还需要促进第4层细胞的命运，这是初级感觉皮层的标志。这些发现提供了一种机制，丘脑皮质轴突补充神经发生和早期命运规范的内在程序。来自哺乳动物丘脑的区域特异性轴突投射在成人新皮质的靶区域中形成独特的细胞组织。这些轴突如何控制神经发生和早期神经元命运的规范知之甚少。通过使用突变小鼠缺乏大多数的丘脑皮质轴突，我们表明，这些轴突是必要的生产和规格的适当数量的第4层神经元在初级感觉区的新生儿阶段。这些区域特异性作用的一部分是由丘脑衍生的分子VGF发挥的。我们的工作表明，从感觉丘脑投射的外在线索有一个早期的作用，通过提高生产和规范的第4层神经元的皮层细胞结构的形成。
This study addresses how the cerebral cortex is partitioned into specialized areas during development. Although both early embryonic patterning and postnatal synaptic input from sensory thalamic nuclei are known to be critical, early roles of thalamic axons in area-specific regulation of cortical neurogenesis are poorly understood. We examined this by developing a genetic mouse model in which thalamocortical projections fail to properly form during embryogenesis, and found these axons are required not only for an enhanced production of superficial layer neurons but also for promoting the layer 4 cell fate, a hallmark of the primary sensory cortex. These findings provide a mechanism by which thalamocortical axons complement the intrinsic programs of neurogenesis and early fate specification. Area-specific axonal projections from the mammalian thalamus shape unique cellular organization in target areas in the adult neocortex. How these axons control neurogenesis and early neuronal fate specification is poorly understood. By using mutant mice lacking the majority of thalamocortical axons, we show that these axons are required for the production and specification of the proper number of layer 4 neurons in primary sensory areas by the neonatal stage. Part of these area-specific roles is played by the thalamus-derived molecule, VGF. Our work reveals that extrinsic cues from sensory thalamic projections have an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.
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影响因子：
16.2
作者：
Cadwell, Cathryn R.;Bhaduri, Aparna;Mostajo-Radji, Mohammed A.;Keefe, Matthew G.;Nowakowski, Tomasz J.
通讯作者：
Nowakowski, Tomasz J.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
16.6
作者：
De Leon Reyes, N. S.;Mederos, S.;Nieto, M.
通讯作者：
Nieto, M.
影响因子：
25
作者：
Fukuchi-Shimogori, T;Grove, EA
通讯作者：
Grove, EA
DOI：
10.1523/jneurosci.5222-10.2011
发表时间：
2011-05-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Callaway EM;Borrell V
通讯作者：
Borrell V