Phototherapy for psoriasis
Phototherapy for psoriasis
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DOI：
10.17816/dv105476
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发表时间：
2022-08
期刊：
影响因子：
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通讯作者：
Olga S. Yazkova;E. M. Anpilogova
中科院分区：
文献类型：
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作者：
Olga S. Yazkova;E. M. Anpilogova
银屑病是一种慢性遗传决定的多因素疾病，与免疫介导的炎症有关，其特点是复发过程中经常伴有其他器官和系统的相关损伤。根据全球建议，如今，尽管生物疗法时代，光疗（PUVA和UVB）继续占据其重要的利基在治疗中重度牛皮癣，由于病理合理的治疗效果，安全性和低成本的程序。本文综述了光疗的作用机制、疗效等方面的详细资料；以及牛皮癣的潜在生物标志物（钙保护蛋白，脂钙蛋白2，抵抗素），这可以提高治疗有效性的准确性评估，并在必要时及时纠正，这将允许更快地达到预期效果，从而改善患者的生活质量。
Psoriasis is a chronic genetically determined disease of a multifactorial nature associated with immune-mediated inflammation and characterized by a recurrent course with frequent associative damage to other organs and systems. According to global recommendations, nowadays, despite the era of biologic therapy, phototherapy (PUVA and UVB) continues to occupy its important niche in the treatment of moderate-to-severe psoriasis, due to the pathogenetically justified therapeutic effect, safety and low cost of procedures. The review provides detailed data on the mechanism of action, the effectiveness of phototherapy; as well as potential biomarkers of psoriasis (calprotectin, lipocalin 2, resistin), which can enhance an accuracy assessment of the effectiveness of the treatment and, if necessary, its timely correction, which will allow faster achievement of the desired effect resulting in improvement of the quality of patients lives.