Innervation and function of rat tail muscles for modeling cauda equina injury and repair.
Innervation and function of rat tail muscles for modeling cauda equina injury and repair.
复制标题
大鼠尾部肌肉的神经支配和功能用于模拟马尾损伤和修复。
DOI：
10.1002/mus.24498
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发表时间：
2015
期刊：
影响因子：
3.4
通讯作者：
Calancie,Blair
中科院分区：
文献类型：
--
作者：
MacKenzie,SamuelJ;Yi,JuneyoungL;Singla,Amit;Russell,ThomasM;Calancie,Blair
引言：马尾神经损伤后，大鼠尾部表现出功能障碍。我们的目标是更好地了解神经支配和肌肉的作用，控制tail.Methods：成年大鼠接受：（1）腹根损伤;（2）尾神经损伤;或（3）映射骶尾骨肌切开术。小肌肉在尾巴本身（intrinsics）的激活进行了比较，较大的腰骶肌作用于尾巴（extrinsics）。1周后进行尾部运动的行为测试。结果：腹根损伤的大鼠表现出多种行为缺陷，而尾神经损伤的大鼠保持了更完整的尾部运动。映射研究揭示了更广泛的重叠myotomes为extrinsic muscles.Conclusions：外在尾肌发挥更大的作用，在大鼠的尾部运动比他们的内在同行，并受多个神经节段。这些发现对马尾神经损伤的未来研究具有重大意义。肌肉神经52：94-102，2015
Introduction:The rat tail exhibits functional impairment after cauda equina injury. Our goal was to better understand the innervation and roles of muscles that control the tail.Methods:Adult rats received either: (1) ventral root injury; (2) caudales nerve injury; or (3) mapping of sacrococcygeal myotomes. Activation of small muscles within the tail itself (intrinsics) was compared with that of larger lumbosacral muscles acting on the tail (extrinsics). Behavioral testing of tail movement was done 1 week later.Results:Rats that received ventral root injury exhibited multiple behavioral deficits, whereas rats with injury to caudales nerves maintained more fully preserved tail movement. Mapping studies revealed much broader overlap of myotomes for extrinsic muscles.Conclusions:Extrinsic tail muscles play a greater role in tail movement in the rat than their intrinsic counterparts and are innervated by multiple neurological segments. These findings have major implications for future research on cauda equina injury.Muscle Nerve52: 94–102, 2015