Sharp, local synchrony among putative feed-forward inhibitory interneurons of rabbit somatosensory cortex
Sharp, local synchrony among putative feed-forward inhibitory interneurons of rabbit somatosensory cortex
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DOI：
10.1152/jn.1998.79.2.567
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发表时间：
1998-02-01
影响因子：
2.5
通讯作者：
Sirota, MG
中科院分区：
文献类型：
--
作者：
Swadlow, HA;Beloozerova, IN;Sirota, MG
初级躯体感觉皮层（S1）的许多疑似抑制性中间神经元（SIN）接受有效的单突触丘脑输入（丘脑皮层SIN，SINstc）。有人提出，几乎所有这样的SINstc的S1桶柱（BC）接收兴奋性突触输入的每个成员的神经元亚群内的地形对齐的腹基底（VB）丘脑barreloid。这样一个发散和收敛的网络导致了几个可测试的预测：急剧同步活动应该发生在BC的SINstc之间，急剧同步不应该发生在相邻BC的SINstc之间，急剧同步不应该发生在SIN或同一BC的其他神经元之间，这些神经元不接受有效的单突触丘脑输入。通过交叉相关相同和相邻BC的SINstc活性来测试这些预测。第5层的下行离皮质神经元（CF-5神经元，确定由逆向激活）和其他神经元，很少或没有单突触VB输入之间的相关性也进行了检查。通过VB刺激引起的三个或更多个尖峰的高频（>600 Hz）爆发来识别SIN，并且SIN具有短持续时间的动作电位。通过短突触潜伏期对VB丘脑的电刺激进一步分化SINstc，
Many suspected inhibitory interneurons (SINs) of primary somatosensory cortex (S1) receive a potent monosynaptic thalamic input (thalamocortical SINs, SINstc). It has been proposed that nearly all such SINstc of a S1 barrel column (BC) receive excitatory synaptic input from each member of a subpopulation of neurons within the topographically aligned ventrobasal (VB) thalamic barreloid. Such a divergent and convergent network leads to several testable predictions: sharply synchronous activity should occur between SINstc of a BC, sharp synchrony should not occur between SINstc of neighboring BCs, and sharp synchrony should not occur between SINs or other neurons of the same BC that do not receive potent monosynaptic thalamic input. These predictions were tested by cross-correlating the activity of SINstc of the same and neighboring BCs. Correlations among descending corticofugal neurons of layer 5 (CF-5 neurons, identified by antidromic activation) and other neurons that receive little or no monosynaptic VB input also were examined. SINs were identified by a high-frequency (>600 Hz) burst of three or more spikes elicited by VB stimulation and had action potentials of short duration. SINstc were further differentiated by short synaptic latencies to electrical stimulation of VB thalamus (