The promise and peril of chemical probes.
The promise and peril of chemical probes.
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DOI：
10.1038/nchembio.1867
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发表时间：
2015-08
影响因子：
14.8
通讯作者：
Zuercher WJ
中科院分区：
文献类型：
--
作者：
Arrowsmith CH;Audia JE;Austin C;Baell J;Bennett J;Blagg J;Bountra C;Brennan PE;Brown PJ;Bunnage ME;Buser-Doepner C;Campbell RM;Carter AJ;Cohen P;Copeland RA;Cravatt B;Dahlin JL;Dhanak D;Edwards AM;Frederiksen M;Frye SV;Gray N;Grimshaw CE;Hepworth D;Howe T;Huber KV;Jin J;Knapp S;Kotz JD;Kruger RG;Lowe D;Mader MM;Marsden B;Mueller-Fahrnow A;Müller S;O'Hagan RC;Overington JP;Owen DR;Rosenberg SH;Roth B;Ross R;Schapira M;Schreiber SL;Shoichet B;Sundström M;Superti-Furga G;Taunton J;Toledo-Sherman L;Walpole C;Walters MA;Willson TM;Workman P;Young RN;Zuercher WJ
化学探针是一种功能强大的试剂，在生物医学研究中的影响越来越大。然而，质量差或使用不当的探头会产生误导性结果。为了帮助解决这些缺点，我们将创建一个社区驱动的wiki资源，以提高质量并传达当前的最佳实践。
Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.