Social experience influences hypothalamic oxytocin in the WHHL rabbit.
Social experience influences hypothalamic oxytocin in the WHHL rabbit.
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社会经历影响 WHHL 兔子的下丘脑催产素。
DOI：
10.1016/j.psyneuen.2006.06.007
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发表时间：
2006
影响因子：
3.7
通讯作者：
McCabe,PhilipM
中科院分区：
文献类型：
--
作者：
Paredes,Jamespaul;Szeto,Angela;Levine,JonE;Zaias,Julia;Gonzales,JulieA;Mendez,ArmandoJ;Llabre,MariaM;Schneiderman,Neil;McCabe,PhilipM
社会经验影响渡边遗传性高脂血症（WHHL）兔的行为和动脉粥样硬化的进展，因此，WHHL兔暴露于一致的，稳定的社会经验表现出更多的亲和社会行为和较少的主动脉粥样硬化相比，其他社会群体。催产素（OT）参与了社会行为和应激反应的表达，并可能提供了社会经验影响WHHL兔动脉粥样硬化形成的机制。本研究探讨急性和慢性变化，中央和外周OT之前和之后WHHL兔暴露于三个社会条件之一。套管植入邻近下丘脑室旁核（PVN）允许慢性采样细胞外OT浓度通过微透析。将家兔暴露于三种社会条件之一：不稳定组，最初不熟悉的家兔在最初一周内每天配对4小时，每周与不同的不熟悉家兔进行类似配对;稳定组;在整个研究期间，相同的2只同窝仔每天配对4小时;以及单独笼养组。在暴露于各自的社会条件之前和之后2小时，从家兔中采集两次PVN透析液和耳缘静脉血液，间隔20天。分析透析液中的OT，并分析血浆中的OT、儿茶酚胺和糖皮质激素。在最初的社会经验之后，任何组的PVN OT都没有变化。相比之下，在连续20天暴露于各自的社会条件后，不稳定组的PVN OT显著增加，但在第22天的社会经历后，稳定组的PVN OT相对不变。在第1天或第22天的2小时社会体验后，任何组的外周OT均未发生变化。外周OT浓度在所有时间均在稳定组中最高。稳定组也表现出显著较少的主动脉粥样硬化，与我们实验室的早期发现一致。本研究的数据表明，WHHL兔暴露的社会经验类型影响PVN OT、社会行为和WHHL兔疾病模型中动脉粥样硬化的进展。
Social experience influences behavior and the progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic (WHHL) rabbit, such that WHHL rabbits exposed to a consistent, stable social experience exhibited more affiliative social behavior and less aortic atherosclerosis compared to other social groups. Oxytocin (OT) has been implicated in the expression of social behavior, stress responses, and may provide a mechanism by which social experience influences atherogenesis in WHHL rabbits. The current study examined acute and chronic changes in central and peripheral OT before and after WHHL rabbits were exposed to one of three social conditions. Cannula implanted adjacent to the hypothalamic paraventricular nucleus (PVN) allowed chronic sampling of extracellular OT concentration via microdialysis. Rabbits were exposed to one of three social conditions: an Unstable group, with initially unfamiliar rabbits paired daily for 4h during the initial week and similarly paired with a different, unfamiliar rabbit each week; a Stable group; with the same 2 littermates paired daily for 4h the entire study; and an Individually Caged group. Dialysates from the PVN and blood from the marginal ear vein were collected twice, 20 days apart, from rabbits before and after 2h of exposure to their respective social condition. Dialysates were assayed for OT and plasma was assayed for OT, catecholamines and glucocorticoids. There were no changes in PVN OT in any group following the initial social experience. In contrast, after 20 consecutive days of exposure to their respective social condition, PVN OT increased significantly in the Unstable group, but was relatively unchanged in the Stable group following the social experience on day 22. Peripheral OT was not altered in any group following the 2h social experience on day 1 or 22. The concentration of peripheral OT was the highest in the Stable group at all times. The Stable group also exhibited significantly less aortic atherosclerosis, consistent with earlier findings from our laboratory. Data from the present study suggest that the type of social experience WHHL rabbits are exposed influences PVN OT, social behavior and the progression of atherosclerosis in the WHHL rabbit model of disease.