Neuroprotection in metabolism-based therapy.
Neuroprotection in metabolism-based therapy.
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DOI：
10.1016/j.eplepsyres.2011.04.016
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发表时间：
2012-07
影响因子：
2.2
通讯作者：
Hartman AL
中科院分区：
文献类型：
--
作者：
Hartman AL
以代谢为基础的疗法已经成功地用于治疗癫痫发作，但对其在其他神经退行性疾病中的应用的研究正在增加。数据显示使用不同形式的代谢为基础的治疗在阿尔茨海默病和帕金森病的人体试验进行了讨论。动物和体外研究揭示了以代谢为基础的治疗这些疾病的机制，以及ALS、衰老、缺血、创伤和线粒体细胞病变。通过考虑基于代谢的治疗在细胞残疾和死亡（特别是凋亡、兴奋毒性和自噬）中的作用，可以获得更多的见解。
Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating the use of different forms of metabolism-based therapy in human trials of Alzheimer disease and Parkinson disease are discussed. Animal and in vitro studies have shed light on metabolism-based therapy’s mechanisms in these diseases, as well as ALS, aging, ischemia, trauma and mitochondrial cytopathies. Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy).