Suppression of the elicitation of the immune response to alloantigen by ultraviolet radiation.
Suppression of the elicitation of the immune response to alloantigen by ultraviolet radiation.
复制标题
抑制紫外线辐射对同种异体抗原引起的免疫反应。
DOI：
10.1097/00007890-198906000-00018
复制
发表时间：
1989
期刊：
影响因子：
6.2
通讯作者：
Ullrich,SE
中科院分区：
文献类型：
--
作者：
Magee,MJ;Kripke,ML;Ullrich,SE
先前的研究已经确定，小鼠暴露于紫外线照射后注射同种异体抗原可以抑制诱导的迟发型超敏反应和抗原特异性的方式排斥同种异体移植物。然而，在临床情况下，移植前几天的紫外线照射可能被证明是不切实际的，因为难以预测供体器官何时可用。因此，本研究的目的是确定暴露于紫外线辐射是否可以抑制同种异体抗原致敏小鼠的免疫反应的激发。这些数据表明，小鼠在注射同种异体抗原后1、3或5天暴露于UV辐射可显著抑制对该同种异体抗原的迟发型超敏反应。这些小鼠的脾脏中存在抑制性T淋巴细胞。这些抑制细胞对最初用于致敏小鼠的抗原具有特异性，因为它们不抑制对不相关的同种异体抗原的应答。此外，来自用同种异体抗原致敏并暴露于UV辐射1、3或5天后的小鼠的脾细胞不能在混合淋巴细胞应答中响应同种异体抗原而增殖。这些细胞确实会对无关的第三方细胞做出反应，再次证明了抑制的特异性。这些数据表明，小鼠在体内暴露于UV辐射可以抑制对同种异体抗原的免疫应答的激发。由于免疫抑制是特异性的致敏抗原，这些数据表明，这可能提供一种新的方法来抑制免疫反应的组织同种异体移植物。
Previous studies have established that exposure of mice to ultraviolet radiation followed by injection of alloantigen can suppress the induction of delayed hypersensitivity and the rejection of allografts in an antigen-specific manner. In the clinical situation, however, UV irradiation several days prior to transplantation may prove impractical due to the difficulty in predicting when a donor organ will be available. Thus, the purpose of this study was to determine if exposure to UV radiation can suppress the elicitation of the immune response in mice sensitized with alloantigen. The data demonstrate that exposure of mice to UV radiation 1, 3, or 5 days after the injection of alloantigen can significantly suppress the delayed hypersensitivity response to that alloantigen. Present in the spleens of these mice are suppressor T lymphocytes. These suppressor cells are specific for the antigen originally used to sensitize the mice, in that they do not suppress the response to an irrelevant alloantigen. In addition, spleen cells from mice sensitized with alloantigen and exposed to UV radiation 1, 3, or 5 days later are unable to proliferate in response to the alloantigen in a mixed lymphocyte response. These cells do respond to irrelevant third-party cells, demonstrating again the specificity of the suppression. These data demonstrate that exposure of mice in vivo to UV radiation can inhibit the elicitation of the immune response to alloantigen. Since the immunosuppression is specific for the sensitizing antigen, these data suggest that this may provide a novel method of suppressing the immune response to tissue allografts.