Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?
Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?
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DOI：
10.1080/09629350400003100
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发表时间：
2004-08
影响因子：
4.6
通讯作者：
Segelmark M
中科院分区：
文献类型：
--
作者：
Ohlsson S;Wieslander J;Segelmark M
目的：抗中性粒细胞胞浆自身抗体相关血管炎(AASV)是一种复发缓解性炎症性疾病。在这里，我们探索疾病不同阶段的细胞因子谱，寻找可能具有预后价值的致病线索。结果：血浆IL-6、IL-8、IL-10水平显著升高。随后发生不良事件的稳定期患者的IL-8值较高。3个月内复发的稳定期患者IL-10水平较低，IL-6水平较高。结论：与健康对照组相比，AASV患者循环细胞因子水平升高，即使在缓解期也是如此。IL-8升高似乎与预后不良有关。较低的IL-10水平和较高的IL-6水平预示着更大的复发风险。临床缓解期的系统性脉管炎患者有持续性的疾病活动，并受到抑制性细胞因子的控制。
AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. RESULTS: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. CONCLUSIONS: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines.
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影响因子：
19.6
作者：
NORONHA, IL;KRUGER, C;WALDHERR, R
通讯作者：
WALDHERR, R
影响因子：
8.8
作者：
Lowe, PR;Galley, HF;Webster, NR
通讯作者：
Webster, NR
影响因子：
13.2
作者：
Dharnidharka, VR;Kwon, C;Stevens, G
通讯作者：
Stevens, G
影响因子：
13.2
作者：
Pecoits, R;Heimbürger, O;Stenvinkel, P
通讯作者：
Stenvinkel, P
影响因子：
15.9
作者：
Ralston, DR;Warsh, CB;Wewers, MD
通讯作者：
Wewers, MD