2 HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA - DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA - AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION
2 HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA - DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA - AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION
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DOI：
10.1111/apm.1965.64.1.31
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发表时间：
1965-01-01
期刊：
影响因子：
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通讯作者：
LAUREN, P
中科院分区：
文献类型：
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作者：
LAUREN, P
通过对1，344例手术标本的组织学和组织化学研究，可将胃癌分为两种主要的组织学类型。肠型胃癌占53%，弥漫型胃癌占33%。这些主要类型的癌在一般结构和细胞结构、粘液分泌和生长方式等方面都有其典型的特征。男性和老年患者的比例在弥漫型组中高于弥漫型组。胃粘膜周围的胃改变和肠化生的发生率和程度在直肠型癌中更大。弥漫型胃癌的预后比浸润型胃癌差。由于消化道型胃癌和弥漫型胃癌不仅在结构上不同，而且在与疾病其他特征的相关性上也不同，因此可以假定它们至少在某种程度上是由不同的病因因素引起的，并且它们在发病机制上也不同。
Two histological main types could be distinguished in gastric carcinomas by a structural and histochemical study of a surgical material comprising 1,344 cases. Intestinal-type carcinoma accounted for 53% and diffuse carcinoma for 33% of all gastric carcinomas. Carcinomas of these main types had their own typical features of general structure and cell structure, secretion of mucus and mode of growth. The proportion of men and older patients was greater in the intestinal-type group than in the group with diffuse carcinoma. Gastritic changes in the surrounding mucosa and the incidence and extent of intestinal metaplasias were greater in intestinal-type carcinomas. The prognosis was poorer in diffuse than in intestinal-type carcinomas. As intestinal-type and diffuse gastric carcinoma differed not only structurally but also in their correlation to the other characteristics of the disease, it might be assumed that they, at least to some extent, are caused by different etiologic factors and that they differ pathogenetically as well.