MATHEMATICAL ANALYSIS AND DIGITAL SIMULATION OF RESPIRATORY CONTROL SYSTEM
MATHEMATICAL ANALYSIS AND DIGITAL SIMULATION OF RESPIRATORY CONTROL SYSTEM
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DOI：
10.1152/jappl.1967.22.2.260
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发表时间：
1967-01-01
影响因子：
3.3
通讯作者：
BART, AJ
中科院分区：
文献类型：
--
作者：
GRODINS, FS;BUELL, J;BART, AJ
肺-血液-组织气体运输和交换系统的基本物质平衡关系用一组包含许多相关时间延迟的微分-差分方程来表达。编写了额外的方程来定义运输和酸碱缓冲、浓度平衡和血流行为的化学细节。最后编写了一个控制函数，定义通气对脑脊液 (H+) 以及颈动脉化学感受器处的动脉 (H+) 和 O2 压力的依赖性。编写了一个 Fortran 程序，用于方便地数字模拟动态系统对各种强迫的响应，包括二氧化碳吸入、海平面缺氧、海拔缺氧和酸碱平衡代谢紊乱。动态和稳态行为都是相当现实的。
The basic material balance relationships for the lung-blood-tissue gas transport and exchange system was expressed in a set of differential-difference equations containing a number of dependent time delays. Additional equations were written to define the chemical details of transport and acid-base buffering, concentration equilibria, and blood flow behavior. Finally a control function was written defining the dependence of ventilation upon cerebospinal fluid (H+), and arterial (H+)and O2 pressure at the carotid chemo-ceptors. A Fortran program was written for convenient digital simulation of the dynamic system responses to a wide variety of forcings including CO2 inhalation, hypoxia at sea level, altitude hypoxia, and metabolic disturbances in acid-base balance. Both dynamic and steady-state behavior was reasonably realistic.