The verification of the reliability of a triglyceride-glucose index and its availability as an advanced tool
The verification of the reliability of a triglyceride-glucose index and its availability as an advanced tool
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DOI：
10.1007/s11306-021-01837-9
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发表时间：
2021-11-01
期刊：
影响因子：
3.6
通讯作者：
Lee, Jong Ho
中科院分区：
文献类型：
--
作者：
Jeong, Sarang;Lee, Jong Ho
背景甘油三酯-葡萄糖（TyG）指数被认为是胰岛素抵抗（IR）的评价指标。本研究旨在验证TyG指标作为IR评价指标的信度；血浆脂肪酸和体脂组成的研究，以确定体重指数（BMI）在25.0至29.9 kg/m之间的潜在代谢综合征（MetS）参与者(2)。方法研究纳入378名体重指数在25.0 ~ 29.9 kg/m(2)之间的超重参与者。根据IR的稳态模型评估（HOMA-IR）或TyG指数将其分为四分之一。采用气相色谱-质谱联用、计算机断层扫描和双能x线吸收仪研究IR评价指标的作用及其与IR相关疾病和危险因素的关系。结果只有在TyG指数高的实验组中，高TyG指数的参与者表现出较高的ldl -胆固醇水平。更明显的是，与HOMA-IR相比，TyG指数与omega-6多不饱和脂肪酸之间存在密切关系。与HOMA-IR不同的是，在患慢性疾病的风险方面，TyG指数的第三个分位数MetS显示，与TyG指数的第一个分位数相比，MetS发生的优势比（OR）约为33.7倍。结论TyG指标可作为IR评价指标。此外，TyG指数是反映促炎症水平与ir相关慢性疾病存在相关性的先进工具。
Background The triglyceride-glucose (TyG) index has been considered as insulin resistance (IR) assessment index. The current study aimed to verify the reliability of the TyG index as an IR assessment marker; the study of plasma fatty acids and body fat composition to determine potential metabolic syndrome (MetS) participants with a body mass index (BMI) of between 25.0 and 29.9 kg/m(2). Methods The study included 378 overweight participants with a body mass index of between 25.0 and 29.9 kg/m(2). They were divided into tertiles according to the homeostasis model assessment of IR (HOMA-IR) or the TyG index. The role of the IR assessment index and the relationship with IR-related diseases and the risk factors using gas chromatograph-mass spectrometry, computed tomography, and dual energy X-ray absorptiometry, was investigated. Results It was only in the TyG index tertile that the higher TyG index participants showed considerably higher LDL-cholesterol levels. More markedly, a close relationship was observed between the TyG index and the omega-6 polyunsaturated fatty acids compared with the HOMA-IR. Unlike HOMA-IR, with regard to the risks of developing chronic diseases, the MetS, the third tertile of the TyG index, showed an approximately 33.7 times greater odds ratio (OR) of the MetS occurring, compared with the first tertile of the TyG index. Conclusions The TyG index may be considered as an IR assessment index. In addition, the TyG index is an advanced tool that reflects the relevance of pro-inflammation levels and the presence of IR-related chronic diseases.