Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation.
Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation.
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DOI：
10.1530/rep-14-0072
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Paul S
中科院分区：
文献类型：
--
作者：
Knott JG;Paul S
哺乳动物的生殖严重依赖于滋养层细胞谱系，这确保了妊娠期间母胎相互作用的正确建立。滋养层细胞谱系的特化始于植入前胚胎滋养外胚层（TE）的发育。随后，其他滋养层细胞类型随着妊娠的进展而出现。转基因动物模型以及滋养层干/祖细胞的研究表明，滋养层谱系发育中存在不同的转录和表观遗传调节因子。本文综述了滋养层细胞的转录和表观遗传调控机制。
Mammalian reproduction is critically dependent on the trophoblast cell lineage, which assures proper establishment of maternal-fetal interactions during pregnancy. Specification of trophoblast cell lineage begins with the development of the trophectoderm (TE) in preimplantation embryos. Subsequently, other trophoblast cell types arise with progression of pregnancy. Studies with transgenic animal models as well as trophoblast stem/progenitor cells have implicated distinct transcriptional and epigenetic regulators in trophoblast lineage development. This review focuses on our current understanding of transcriptional and epigenetic mechanisms regulating specification, determination, maintenance and differentiation of trophoblast cells.