Prognostic impact of ploidy level in carcinoma of the cervix
Prognostic impact of ploidy level in carcinoma of the cervix
复制标题
倍性水平对宫颈癌预后的影响
DOI：
10.1097/00000421-198410000-00016
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
A. Jakobsen
中科院分区：
文献类型：
--
作者：
A. Jakobsen
应用流式细胞术分析宫颈癌单细胞DNA含量。该研究包括171名Ib-III期患者。通过与二倍体淋巴细胞比较，计算倍性水平作为DNA指数。因此，肿瘤被分为DNA指数低于和高于1.5的两组。这种划分被证明是重要的复发频率。在研究的所有阶段中，在DNA指数高于1.5的组中发现统计学显著更高的复发频率。同样的关系也适用于生存期。因此，DNA分布是宫颈癌的一个重要预后因素。
THE SINGLE CELL DNA CONTENT WAS ANALYZED BY USE of flow cytometry in cervical carcinoma. The study included 171 patients, Stages Ib-III. The ploidy level was calculated as a DNA index by comparison with diploid lymphocytes. Accordingly, the tumors were divided into two groups with DNA index below and above 1.5. This division proved to be important to the recurrence frequency. In all stages investigated, a statistically significant higher recurrence frequency was found in the group with DNA index above 1,5. The same relation applied concerning the survival It is concluded that the DNA distribution is an important prognostic factor in cervical carcinoma.