Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases.
Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases.
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DOI：
10.1093/noajnl/vdab123
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Lockman PR
中科院分区：
文献类型：
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作者：
Blethen KE;Arsiwala TA;Fladeland RA;Sprowls SA;Panchal DM;Adkins CE;Kielkowski BN;Earp LE;Glass MJ;Pritt TA;Cabuyao YM;Aulakh S;Lockman PR
血脑屏障是大脑选择性渗透的脉管系统，对于维持体内平衡和神经功能至关重要。低渗透性对于血液中存在毒素和病原体是有益的。然而，在存在转移性脑肿瘤的情况下，这对药物输送是一个挑战。尽管血肿瘤屏障有轻微渗漏，但它仍然不足以允许治疗药物浓度在脑转移瘤中积聚。在此，我们讨论原发性脑肿瘤和转移性脑肿瘤脉管系统之间的差异、治疗对血肿瘤屏障的影响，以及为了更有效的药物输送而需要操纵的特征。
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challenge for drug delivery. Although the blood-tumor barrier is slightly leaky, it still is not permissive enough to allow the accumulation of therapeutic drug concentrations in brain metastases. Herein, we discuss the differences between primary brain tumors and metastatic brain tumors vasculature, effects of therapeutics on the blood-tumor barrier, and characteristics to be manipulated for more effective drug delivery.