Curdepsidones B-G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10
Curdepsidones B-G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10
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Curdepsidones B–G，来自海洋衍生真菌 Curvularia sp 的具有抗炎活性的六种 Depsidones。
DOI：
10.3390/md17050266
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发表时间：
2019-05-01
期刊：
影响因子：
5.4
通讯作者：
Lu, Yanhua
中科院分区：
文献类型：
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作者：
Ding, Yi;An, Faliang;Lu, Yanhua
从海洋真菌弯孢霉（Curvularia sp.）IFB-Z 10中分离得到6个新的缩酚酮化合物，命名为curdependolones B-G（1-6）。通过HRESIMS和1D/2D-NMR数据的综合分析确定了它们的平面结构。采用密度泛函理论/核磁共振（DFT/NMR）和含时密度泛函理论/电子圆二色性（TDDFT/ECD）计算方法，确定了莪术酮B-C（1-2）的绝对构型.在痤疮丙酸杆菌诱导的THP-1细胞中测试部分分离的化合物的抗炎活性。Curdepsidone C（2）显示出显著的抗炎特性，IC 50值为7.47 +/- 0.35 M，并以剂量依赖性机制降低痤疮丙酸杆菌诱导的JNK和ERK磷酸化水平。通过分子对接研究了2的抗炎作用机制。
Six new depsidones, curdepsidones B-G (1-6), were obtained from the marine-derived fungus Curvularia sp. IFB-Z10. Their planar structures were determined by comprehensive analysis of HRESIMS and 1D/2D-NMR data. The absolute configuration of curdepsidones B-C (1-2) were established by synergistic use of DFT/NMR (density functional theory/nuclear magnetic resonance) and TDDFT/ECD (time-dependent density functional theory/electronic circular dichroism) calculations. Partial isolated compounds were tested for their anti-inflammatory activities in Propionibacterium acnes-induced THP-1 cells. Curdepsidone C (2) displayed significant anti-inflammatory properties with an IC50 value of 7.47 +/- 0.35 M, and reduced the P. acnes-induced phosphorylation levels of JNK and ERK in a dose-dependent mechanism. The possible anti-inflammatory mechanism of 2 was also investigated by molecular docking.