Cell cycles in cell hierarchies.
Cell cycles in cell hierarchies.
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细胞层次结构中的细胞周期。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
C. Potten
中科院分区：
文献类型：
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作者：
C. Potten
在身体的替代组织中，即骨髓、睾丸和具有其附属物的表面上皮，细胞替代似乎是使用分层组织的增殖区室来实现的，其中相对较少的最终干细胞产生分裂的转运细胞，所述转运细胞最终分化并成熟为组织的功能细胞。细胞周期的不同层次的组成部分的时间不同，干细胞显然有一个较长的细胞周期比过境细胞。在某些情况下，例如在骨髓中，当细胞通过转运群体时，细胞周期可能存在变化，而在其他情况下，周期时间保持相当恒定，例如在睾丸中。干细胞和转运细胞之间的细胞周期时间差异并不完全明确，舌背表面上皮细胞的周期时间差异很小或没有差异，而在其他情况下，长干细胞周期的实验证据有些不精确。然而，小肠上皮细胞和睾丸精原细胞已被广泛研究，这里的证据清楚地表明，随着更多的原始细胞被考虑，细胞周期延长。
In the replacing tissues of the body, namely the bone marrow, testis, and the surface epithelia with their appendages, cell replacement would appear to be achieved using an hierarchically organized proliferative compartment with relatively few ultimate stem cells producing dividing transit cells which eventually differentiate and mature into the functional cells of the tissue. The cell cycle times of the various constituents of the hierarchy differ, and the stem cells apparently have a longer cell cycle than the transit cells. There may be variations in the cell cycle as cells pass through the transit population in some cases, e.g. in the bone marrow, while in others the cycle time remains fairly constant, e.g. in the testis. The difference in the cell cycle time between stem cells and transit cells is not completely unequivocal, and there is little or no difference in cycle time in the epithelium on the dorsal surface of the tongue while in other cases the experimental evidence for long stem-cell cycles is somewhat imprecise. However, the epithelium in the small intestine and the spermatogonia in the testis have been fairly extensively studied and here the evidence clearly shows a lengthening of the cell cycle as more primitive cells are considered.