The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
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DOI：
10.1097/00132578-200301000-00007
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发表时间：
2002-06
影响因子：
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通讯作者：
M. Gordon;J. Beiser;J. Brandt;D. Heuer;E. Higginbotham;Chris A. Johnson;J. Keltner;J. Miller;
中科院分区：
文献类型：
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作者：
M. Gordon;J. Beiser;J. Brandt;D. Heuer;E. Higginbotham;Chris A. Johnson;J. Keltner;J. Miller;
背景：眼压升高治疗研究(OHTS)表明，在眼压升高(高眼压)且无青光眼损害的个体中，局部用药能有效延缓或预防原发性开角型青光眼(POAG)的发生。目的描述预测OHTS患者发生开角型青光眼(POAG)的基线人口统计学和临床因素。方法在随机化前收集基线人口学和临床数据，在随机化前测量角膜厚度，并在随机化过程中进行测量。比例风险模型被用来确定预测OHTS中哪些参与者患上POAG的因素。结果在单因素分析中，预测POAG发生的基线因素包括年龄、种族(非裔美国人)、性别(男性)、较大的垂直杯盘比、较大的水平杯盘比、较高的眼压、较大的Humphrey视野模式标准差、心脏病和较薄的中央角膜测量值。在多变量分析中，预测POAG发展的基线因素包括年龄较大、较大的垂直或水平杯盘比、较高的眼压、较大的模式标准差和较薄的中央角膜测量值。结论基线年龄、垂直和水平杯盘比、图形标准差和眼压是预测OHTS患者POAG发病的良好指标。角膜中央厚度是预测POAG发生的重要指标。
BACKGROUND The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. OBJECTIVE To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. METHODS Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. RESULTS In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. CONCLUSIONS Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.