Factors affecting the specific activity of [18F]fluoride from a [18O] water target
Factors affecting the specific activity of [18F]fluoride from a [18O] water target
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DOI：
10.3413/nukmed-0133
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发表时间：
2008-01-01
影响因子：
1.5
通讯作者：
Steinbach, J.
中科院分区：
文献类型：
--
作者：
Fuechtner, F.;Preusche, S.;Steinbach, J.
目的：表征用于生产F-18活度的水靶系统的不同聚合物管材料对放射性示踪剂比活度的影响。材料，方法：从旋风(R)18/9回旋加速器的F-18水靶系统的不同位置采集的目标水样，配备特氟龙(R)(PTFE)或聚丙烯(PP)管，分析非放射性[F-19]氟含量。[F-19]用离子色谱仪(IC20，Dinoex)结合抑制电导检测测定氟含量。在标记合成开始时，离子色谱结果和产生的F-18活度都被用于计算[F-18]氟化物的比活度(SA)。为了验证这些结果，还用不同的管材测定了标记的受体配体[F-18]ZK811460的SA。结果：靶标分配(加载)系统的剂量暴露的聚四氟乙烯管被确定为[F-19]氟污染的主要来源。结论：用PP管替代靶分配系统中的聚四氟乙烯管，可显著降低F-19的含量，使放射性示踪剂[F-18]ZK811460的SA提高一倍。
Aim: Characterisation of the influence of different polymeric tube materials of a water target system, used for the production of F-18 activity, on the specific activity of radiotracers. Material, methods: Target water samples taken from different locations of the F-18 water target system of a Cyclone (R) 18/9 cyclotron, equipped with Teflon (R) (PTFE) or polypropylene (PP) tubes, were analyzed for non-radioactive [F-19]fluoride content. [F-19]Fluoride content was measured by ion chromatography (IC20, Dinoex) with suppressed conductivity detection. Both the ion chromatographic results and the amount of F-18 activity produced were used for the calculation of the specific activity (SA) of [F-18]fluoride at the start of the labelling synthesis. To check these results, the SA of the labelled receptor ligand [F-18]ZK811460 was also determined by using the different tubing materials. Results: Dose-exposed PTFE tubes of the target dispensing (loading) system were identified to be a major source of [F-19]fluoride contamination. Conclusion: By replacing PTFE tubes of the target dispensing system with PP tubes, the content of F-19 was reduced considerably resulting in an increase of SA of the radiotracer [F-18]ZK811460 by factor of two.