Harms of screening mammography for breast cancer in Japanese women
Harms of screening mammography for breast cancer in Japanese women
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DOI：
10.1007/s12282-012-0333-6
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发表时间：
2013-10-01
期刊：
影响因子：
4
通讯作者：
Ohuchi, Noriaki
中科院分区：
文献类型：
--
作者：
Kasahara, Yoshio;Kawai, Masaaki;Ohuchi, Noriaki
美国预防服务工作组通过其益处和危害的总和来评估乳腺癌筛查的有效性，并建议反对常规筛查乳房X光检查，因为其对40-49岁女性的危害相对较大。对筛查性乳房X光检查的有效性进行评估时，不仅要考虑其益处，还要考虑其危害，但日本女性缺乏关于这些危害的数据。2008年，我们收集了来自日本5个都道府县的144，848名年龄段参与者的筛查性乳房X光检查数据，以评估其危害[假阳性结果，不必要的额外成像的执行，40-49岁妇女的癌症检出率为0.28%。40-49岁女性的假阳性率（9.6%）以及乳腺X线摄影（5.8%）和超声（7.3%）的额外成像率高于其他年龄段。40-49岁女性的FNA（1.6%）和活检（0.7%）率也最高。然而，它们似乎低于乳腺癌监测联盟（BCSC）和美国其他研究报告的比率。尽管是初步的结果，但表明日本女性筛查乳房X光检查的危害可能小于美国女性。
The US Preventative Services Task Force assesses the efficacy of breast cancer screening by the sum of its benefits and harms, and recommends against routine screening mammography because of its relatively great harms for women aged 40-49 years. Assessment of the efficacy of screening mammography should take into consideration not only its benefits but also its harms, but data regarding those harms are lacking for Japanese women.In 2008 we collected screening mammography data from 144,848 participants from five Japanese prefectures by age bracket to assess the harms [false-positive results, performance of unnecessary additional imaging, fine-needle aspiration cytology (FNA), and biopsy and its procedures].The rate of cancer detected in women aged 40-49 years was 0.28%. The false-positive rate (9.6%) and rates of additional imaging by mammography (5.8%) and ultrasound (7.3%) were higher in women aged 40-49 years than in the other age brackets. The rates of FNA (1.6%) and biopsy (0.7%) were also highest in women aged 40-49 years. However, they seemed to be lower than the rates reported by the Breast Cancer Surveillance Consortium (BCSC) and other studies in the US.The results, although preliminary, indicate the possibility that the harms of screening mammography for Japanese women are less than those for American women.