Performance of the Japanese GFR equation in potential kidney donors
Performance of the Japanese GFR equation in potential kidney donors
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DOI：
10.1007/s10157-012-0586-6
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发表时间：
2012-06-01
影响因子：
2.3
通讯作者：
Matsuo, Seiichi
中科院分区：
文献类型：
--
作者：
Horio, Masaru;Yasuda, Yoshinari;Matsuo, Seiichi
日本GFR方程主要由慢性肾脏病（CKD）受试者开发。GFR方程的开发和验证中仅纳入了少量健康受试者。我们评估了该方程在潜在肾脏捐献者中的表现，共包括113名潜在肾脏捐献者。还纳入了既往报告的CKD受试者数据进行比较。通过菊粉清除率测量GFR（mGFR）。通过日本GFR方程计算估计的GFR（eGFR）。340例CKD受试者的eGFR和mGFR之间无显著性差异（分别为54.2 +/- A 31.6和55.7 +/- A 33.2 ml/min/1.73 m（2））。113例潜在肾脏供体的eGFR显著低于mGFR（分别为78.9 +/- A 16.2和93.6 +/- A 19.2 ml/min/1.73 m（2））。eGFR 30-59和60-89 ml/min/1.73 m（2）的潜在肾脏供体的偏倚显著大于CKD受试者（潜在肾脏供体分别为-19.2 +/- A 12.2和-18.3 +/- A 16.4 ml/min/1.73 m（2），CKD受试者分别为-3.8 +/- A 15.6和-3.4 +/- A 17.6 ml/min/1.73 m（2））。潜在肾脏供体的肌酐排泄量/体重显著高于CKD受试者，表明潜在肾脏供体的肌酐生成量较高。日本GFR方程低估了潜在肾脏供体的GFR。与CKD受试者相比，肌酐生成量较高可能导致日本GFR方程低估潜在肾脏供体的GFR。
Japanese GFR equation was developed from mainly chronic kidney disease (CKD) subjects. Only a small number of healthy subjects were included in the development and validation of the GFR equation. We assessed the performance of the equation in potential kidney donors.A total of 113 potential kidney donors was included. The data of CKD subjects that were previously reported were also included for comparison. GFR (mGFR) was measured by inulin clearance. The estimated GFR (eGFR) was calculated by the Japanese GFR equation. Bias of the equation (eGFR - mGFR) and urinary creatinine excretion were evaluated.There was no significant difference between eGFR and mGFR in 340 CKD subjects (54.2 +/- A 31.6 and 55.7 +/- A 33.2 ml/min/1.73 m(2), respectively). Contrarily, the eGFR was significantly lower than mGFR in 113 potential kidney donors (78.9 +/- A 16.2 and 93.6 +/- A 19.2 ml/min/1.73 m(2), respectively). The biases in potential kidney donors with eGFR 30-59 and 60-89 ml/min/1.73 m(2) were significantly greater than those in CKD subjects (-19.2 +/- A 12.2 and -18.3 +/- A 16.4 ml/min/1.73 m(2) in potential kidney donors and -3.8 +/- A 15.6 and -3.4 +/- A 17.6 ml/min/1.73 m(2) in CKD subjects, respectively). Creatinine excretion per body weight of potential kidney donors was significantly higher than that of CKD subjects, suggesting higher creatinine generation in potential kidney donors.The Japanese GFR equation underestimated GFR in potential kidney donors. Higher creatinine generation compared with CKD subjects may contribute to the underestimation of GFR by the Japanese GFR equation in potential kidney donors.