Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome
Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome
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发表时间：
2010
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通讯作者：
H. Nanjing
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作者：
H. Nanjing
口腔鳞状细胞癌是一个具有挑战性的肿瘤学问题。一个可靠的生物标志物在口腔癌患者中的转移或高危预后仍然没有确定。我们使用定量免疫组织化学方法检测了83例口腔鳞状细胞癌患者中波形蛋白、E-钙粘蛋白和β-连环蛋白的表达，并分析其表达与临床病理特征的关系，波形蛋白（vimentin 43例肿瘤患者中有23例（53%）最终出现复发肿瘤，并与复发和死亡相关在43例复发性肿瘤患者中，36例（84%）E-cadherin表达降低，与复发和死亡有关尽管在整个肿瘤切片中β-连环蛋白表达与临床病理特征之间没有观察到相关性，但在肿瘤浸润前沿β-连环蛋白表达的降低与复发和死亡密切相关（P=0.002和0.002，vimentin和E-在单因素和多因素分析中，vimentin和cadherin与生存率相关，是独立的预后因素。我们的数据显示，vimentin的过度表达与口腔鳞癌的复发和死亡密切相关。波形蛋白的上调和E-钙粘蛋白/β-连环蛋白复合物在肿瘤浸润前沿的异常表达的组合可以提供口腔鳞状细胞癌中有用的预后标志物。
Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P 0.001 and 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P 0.001 and 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma.