Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends.
Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends.
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DOI：
10.1016/j.jconrel.2011.01.006
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发表时间：
2011-06-30
期刊：
影响因子：
--
通讯作者：
Blankschtein D
中科院分区：
文献类型：
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作者：
Polat BE;Hart D;Langer R;Blankschtein D
使用超声波将药物输送到或穿过皮肤通常称为超声透入疗法或声透疗法。治疗性超声和高频超声（≥ 0.7 MHz）用于超声导入（HFS）的历史早在 20 世纪 50 年代就已开始，而低频超声导入（LFS，20 – 100 kHz）仅在过去二十年才得到广泛研究。尽管 HFS 和 LFS 很相似，因为它们都利用超声波来增加渗透物的皮肤渗透性，但与每种物理增强剂相关的机制不同。具体来说，空化的位置以及每个过程增加皮肤渗透性的程度是非常不同的。尽管这两种技术的应用不同，但它们各自都有优势，可以改进当前的局部、区域和全身药物输送方法。在这篇综述中，我们将讨论与 HFS 和 LFS 相关的机制，特别关注这两种皮肤治疗方法之间的关键机制差异。还将讨论与通过水介质传输的超声波相关的相关物理背景，以及这些现象对超声导入的影响。最后，对文献进行了彻底的回顾，可以追溯到首次发表的超声导入报告，包括对该领域新兴趋势的讨论。
The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥ 0.7 MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20 – 100 kHz) has only been investigated significantly during the past two decades. Although HFS and LFS are similar because they both utilize ultrasound to increase the skin penetration of permeants, the mechanisms associated with each physical enhancer are different. Specifically, the location of cavitation and the extent to which each process can increase skin permeability are quite dissimilar. Although the applications of both technologies are different, they each have strengths that could allow them to improve current methods of local, regional, and systemic drug delivery. In this review, we will discuss the mechanisms associated with both HFS and LFS, specifically concentrating on the key mechanistic differences between these two skin treatment methods. Background on the relevant physics associated with ultrasound transmitted through aqueous media will also be discussed, along with implications of these phenomena on sonophoresis. Finally, a thorough review of the literature is included, dating back to the first published reports of sonophoresis, including a discussion of emerging trends in the field.