Rebreathing techniques for pulmonary capillary blood flow and tissue volume.
Rebreathing techniques for pulmonary capillary blood flow and tissue volume.
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肺毛细血管血流量和组织容量的再呼吸技术。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Fernandez
中科院分区：
文献类型：
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作者：
M. Sackner;G. Markwell;N. Atkins;S. Birch;R. Fernandez
使用乙炔、碘乙烷和二甲醚作为标记物，在正常人中评估了计算再呼吸期间肺毛细血管血流量 (Qc) 和肺组织加毛细血管血容量 (Vt) 的三种方法的变异性。分析方法如下。方法一，通过假设C18O-消失曲线在时间O处截取来校正可溶性气体消失曲线的时间。方法二，假设方法一计算的乙炔Qc是正确的；使用这些气体的消失斜率和乙炔 Qc 值通过方程求解乙基碘和二甲醚 Vt，从而避免依赖于外推截距值。方法III，通过求解乙炔和二甲醚、乙炔和碘乙烷以及碘乙烷和二甲醚的消失斜率对之间Qc的唯一值来计算Vt。在这三种方法中，方法 I 给出了用乙炔或二甲醚测定的 Vt 的重现性最高的值。使用方法 I，乙炔和二甲醚都是同样可接受的 Vt 测量气体；乙炔是 Qc 测量的更好标记。
The variability of three methods of calculating pulmonary capillary blood flow (Qc) and pulmonary tissue plus capillary blood volume (Vt) during rebreathing was assessed in normal humans by using as markers acetylene, ethyl iodide, and dimethyl ether. The methods of analysis were as follows. Method I, the timing of the disappearance curves of the soluble gases was corrected by assuming that the C18O-disappearance curve intercepted at unity at time O. Method II, it was assumed that the acetylene Qc calculated by method I was correct; ethyl iodide and dimethyl ether Vt were solved by an equation using the disappearance slopes of these gases and the acetylene Qc value, thereby avoiding dependence on extrapolated intercept values. Method III, Vt was calculated by solving for a unique value of Qc between pairs of disappearance slopes of acetylene and dimethyl ether, acetylene and ethyl iodide, and ethyl iodide and dimethyl ether. Among the three methods, method I gave the most reproducible values for Vt as determined with acetylene or dimethyl ether. Using method I, both acetylene and dimethyl ether were equally acceptable gases for measurement of Vt; acetylene was a better marker for Qc measurements.