Flow territory mapping of the cerebral arteries with regional perfusion MRI
Flow territory mapping of the cerebral arteries with regional perfusion MRI
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DOI：
10.1161/01.str.0000120312.26163.ec
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发表时间：
2004-04-01
期刊：
影响因子：
8.3
通讯作者：
Golay, X
中科院分区：
文献类型：
--
作者：
Hendrikse, J;van der Grond, J;Golay, X
背景和目的-传统对比增强血管造影是主要脑动脉供应的血管树可视化和侧支血流评估的金标准。然而，到目前为止，还没有方法可以评估单个脑动脉的实际血流区域。在本研究中，我们评估了一种非侵入性动脉自旋标记 MRI 方法，用于选择性绘制左、右颈内动脉和后循环（基底动脉和椎动脉）的流动区域。方法——基于脉冲动脉自旋标记序列对动脉水进行选择性平板反转，开发了一种空间选择性标记方法，即区域灌注成像。证明了该方法的选择性。结果-区域灌注成像能够评估主要脑动脉的灌注区域。通过选择性标记颈内动脉，信号存在于同侧大脑前动脉和同侧大脑中动脉血流区域中。通过标记基底动脉，灌注加权信号对称地存在于两个大脑后动脉血流区域中。在整个半球（40.1 mL . min(-1) . 100 g(-1) 组织）、白质（22.1 mL . min(-1) . 100 g(-1) 组织）和灰质（65.8 mL . min(-1) . 100 g(-1) 组织）中使用区域灌注成像测量的脑血流值与数据一致。结论——我们提出了第一种能够定量和定性评估体内单个脑供血动脉血流区域的成像方法。
Background and Purpose-Conventional contrast-enhanced angiography is the gold standard for visualization of the vascular tree supplied by the major cerebral arteries and assessment of collateral flow. Thus far, however, no methods are available to assess the actual flow territories of the individual cerebral arteries. In the present study, we evaluate a noninvasive arterial spin labeling MRI method for selective mapping of the flow territories of the left and right internal carotid arteries and posterior circulation (basilar artery and vertebral arteries).Methods-A spatially selective labeling approach, regional perfusion imaging, was developed on the basis of selective slab inversion of the arterial water with a pulsed arterial spin labeling sequence. The selectivity of this method was demonstrated.Results-Regional perfusion imaging enables assessment of the perfusion territories of the major cerebral arteries. With selective labeling of an internal carotid artery, signal is present in both the ipsilateral anterior cerebral artery and ipsilateral middle cerebral artery flow territory. With labeling of the basilar artery, perfusion-weighted signal is symmetrically present in both posterior cerebral artery flow territories. Cerebral blood flow values measured with regional perfusion imaging in the complete hemisphere (40.1 mL . min(-1) . 100 g(-1) tissue), white matter (22.1 mL . min(-1) . 100 g(-1) tissue), and gray matter (65.8 mL . min(-1) . 100 g(-1) tissue) are in agreement with data in the literature.Conclusions-We present the first imaging method capable of evaluating both quantitatively and qualitatively the flow territories of the individual brain-feeding arteries in vivo.