INDUCTION OF PHAGE FORMATION IN THE LYSOGENIC ESCHERICHIA-COLI K-12 BY MITOMYCIN-C
INDUCTION OF PHAGE FORMATION IN THE LYSOGENIC ESCHERICHIA-COLI K-12 BY MITOMYCIN-C
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DOI：
10.1038/1841079b0
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发表时间：
1959-01-01
期刊：
影响因子：
64.8
通讯作者：
TAKAGI, Y
中科院分区：
文献类型：
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作者：
OTSUJI, N;SEKIGUCHI, M;TAKAGI, Y
MITOMYCINC是一种新分离的抗生素，由于其抗肿瘤活性以及对细菌脱氧核糖核酸合成的选择性抑制作用而受到特别关注。1还观察到，经丝裂霉素C处理的大肠杆菌B细胞脱氧核糖核酸合成受损的情况可以通过感染噬菌体T2r2迅速恢复。这些性质表明，这种抗生素可以诱导溶原菌中活性噬菌体从原噬菌体状态发展起来，因为它们类似于紫外线的作用。这种交流涉及到外加丝裂霉素诱导的大肠杆菌K-12的裂解过程。
MITOMYCINC, a newly isolated antibiotic, is receiving special attention because of its anti-neo-plastic activity as well as its selective inhibitory action on the synthesis of bacterial deoxyribonucleic acid.1It has also been observed that the impaired deoxyribonucleic acid synthesis of cells ofEscherichia coli Btreated with mitomycinCcan be promptly restored by infection with the bacteriophageT2r2. These properties suggested that this antibiotic could induce the development of active phage from the prophage state in lysogenic bacteria, since they are similar to ultra-violet effects. This communication concerns the lytic process ofEscherichia coliK–12 induced by mitomycinCadded externally.