Brief Report: Accuracy in Self-Report of Viral Suppression Among HIV-Positive Men With HIV-Negative Male Partners.
Brief Report: Accuracy in Self-Report of Viral Suppression Among HIV-Positive Men With HIV-Negative Male Partners.
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DOI：
10.1097/qai.0000000000002240
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发表时间：
2020-03-01
期刊：
影响因子：
--
通讯作者：
Sullivan PS
中科院分区：
文献类型：
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作者：
Stephenson R;Bratcher A;Mimiaga MJ;Garofalo R;Hidalgo MA;Hoehnle S;Sullivan PS
在男男性行为者（MSM）中，现在有明确的证据表明，当艾滋病毒阳性伴侣的病毒受到抑制时，通过无安全套性行为传播艾滋病毒的风险实际上为零。然而，了解血清不一致的同性男性夫妇之间的病毒载量报告的准确性是从文献中缺失。这项分析使用的数据来自基线样本的更强在一起，一个随机对照的疗效试验的创新的二元干预，以提高抗逆转录病毒治疗的依从性艾滋病毒血清不一致的男性夫妇在美国三个城市（亚特兰大，波士顿和芝加哥）。使用生物标志物确认的和自我报告的病毒载量测量值评估自我报告的病毒抑制的准确性。在这一描述性分析中，不准确报告病毒抑制的男性百分比在人口统计学、关系和艾滋病毒护理特征方面进行了比较。结果证实了最近其他研究的结果，这些研究表明，在报告病毒抑制方面存在相对较高的不准确性。尽管72.5%的男性可以准确报告他们的病毒载量状态，但20%的男性报告说，当他们没有生物标志物证实的病毒抑制措施时，他们受到病毒抑制。这些结果突出表明，有必要为感染艾滋病毒的男男性行为者提供干预措施，以支持获得护理，并确保目前对病毒载量的了解，并继续通过使用安全套和暴露前预防（PrEP）支持艾滋病毒的初级预防。对于夫妇，特别是血清不一致的男性夫妇，干预措施，可以教夫妇如何合作，以实现和保持病毒抑制的积极合作伙伴是一个紧迫和务实的方案优先事项，可以装备夫妇正确执行U=U战略所需的知识。
Among men who have sex with men (MSM), there is now clear evidence that the risk of HIV transmission through condomless sex when the HIV-positive partner is virally suppressed is effectively zero. However, an understanding of the accuracy of reporting of viral load among serodiscordant same-sex male couples is missing from the literature. This analysis uses data from the baseline sample of Stronger Together, a randomized controlled efficacy trial of an innovative dyadic intervention to enhance antiretroviral therapy adherence for HIV serodiscordant male couples in three US cities (Atlanta, Boston and Chicago). Biomarker-confirmed and self-reported measures of viral load were used to assess the accuracy of self-report of viral suppression. In this descriptive analysis, the percentage of men who inaccurately reported being virally suppressed is compared across demographic, relationship and HIV care characteristics. Results confirm those of other recent studies that have shown relatively high levels of inaccuracy in reporting of viral suppression. Although 72.5% of men could accurately report their viral load status, 20% reported that they were virally suppressed when they did not have a biomarker confirmed measure of viral suppression. These results highlight the need to provide interventions to MSM living with HIV to support access to care and ensure current knowledge of viral load, and to continue to support primary prevention of HIV through condom use and pre-exposure prophylaxis (PrEP). For couples, particularly serodiscordant male couples, interventions that can teach the couple how to collaborate to achieve and maintain viral suppression for the positive partner are an urgent and pragmatic programmatic priority that can equip couples with the knowledge required to correctly implement U=U strategies.