INCIDENCE AND RISK-FACTORS FOR THROMBOTIC COMPLICATIONS IN A HISTORICAL COHORT OF 100 PATIENTS WITH ESSENTIAL THROMBOCYTHEMIA
INCIDENCE AND RISK-FACTORS FOR THROMBOTIC COMPLICATIONS IN A HISTORICAL COHORT OF 100 PATIENTS WITH ESSENTIAL THROMBOCYTHEMIA
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DOI：
10.1200/jco.1990.8.3.556
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发表时间：
1990-03-01
影响因子：
45.3
通讯作者：
BARBUI, T
中科院分区：
文献类型：
--
作者：
CORTELAZZO, S;VIERO, P;BARBUI, T
本研究的目的是确定哪些因素与100名连续的和连续的原发性血小板增多症（ET）患者的历史队列中血栓出血并发症的风险增加有关，其中当血小板超过1，000 ×时给予白消安治疗。109/L和/或发生重大血栓形成或出血事件。与血栓形成事件（6.6%/患者-年）相比，严重出血性并发症的发生率非常低（0.33%/患者-年）。在200例患者的充分和适当的对照历史组中，未记录严重血栓形成，血栓形成事件的发生率为1.2%患者-年。因此，风险因素分析仅限于后一组事件。年龄、既往血栓形成事件和血小板增多持续时间长被确定为血栓形成的主要危险因素，而吸烟、糖尿病、高脂血症和高血压不影响血栓形成事件的发生率。
The purpose of this study was to determine which factors were associated with an increased risk of thrombo-hemorrhagic complications in a historical cohort of 100 consecutive and unselected patients with essential thrombocythemia (ET) in whom busulfan treatment was given when platelets were more than 1,000 .times. 109/L and/or a major thrombotic or hemorrhagic event occurred. The incidence of major hemorrhagic complications was very low (0.33%/person-time at risk [pt-yr)] in comparison with that of thrombotic episodes (6.6%/pt-yr). In an adequate and appropriate control historical group of 200 patients, no severe hemorrhages were recorded and the incidence of thrombotic events was 1.2% pt-yr. Thus, the analysis of risk factors was restricted to this latter group of events. Age, a previous thrombotic event, and long duration of thrombocytosis were identified as major risk factors for thrombosis, while smoking, diabetes mellitus, hyperlipidemia, and hypertension did not influence the rate of thrombotic episodes.