Genetic moderation of sensitivity to positive and negative affect in marriage.
Genetic moderation of sensitivity to positive and negative affect in marriage.
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对婚姻中积极和消极影响的敏感性的遗传调节。
DOI：
10.1037/a0026067
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Bradbury,ThomasN
中科院分区：
文献类型：
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作者：
Schoebi,Dominik;Way,BaldwinM;Karney,BenjaminR;Bradbury,ThomasN
假设遗传因素部分地控制了对人际关系线索的敏感性，我们研究了5-羟色胺转运体基因的多态性（5-HTTLPR）是否会调节配偶对积极和消极伴侣影响的敏感性。在婚姻讨论之前和之后，来自76对夫妇（共n= 150）的参与者报告了他们的情感状态。携带5-HTTLPR短等位基因的配偶比携带两个长等位基因的配偶对伴侣的预互动积极情感和焦虑/紧张更敏感。这些数据支持了血清素系统影响对社会刺激的情感反应的论点。与5-HTTLPR主要影响对不良经历的反应的观点相反，这些结果表明，这种多态性调节了对积极和消极影响的敏感性。
Hypothesizing that genetic factors partially govern sensitivity to interpersonal cues, we examined whether a polymorphism (5-HTTLPR) in the serotonin transporter gene would moderate spouses' sensitivity to positive and negative partner affect. Before and after marital discussions, participants from 76 couples (total n= 150) reported their affective states. Spouses carrying the short allele of the 5-HTTLPR were more responsive to their partner's preinteraction positive affect and anxiety/nervousness, compared with spouses with two long alleles. These data support the contention that the serotonin system influences affective responses to social stimuli. In contrast to the view that the 5-HTTLPR primarily affects response to adverse experiences, these results suggest that this polymorphism moderates sensitivity to positive as well as negative affect.