Validating Homogeneity for a Novel 3-Dimensional Tissue Phantom Modeling System of the Human Maxilla.
Validating Homogeneity for a Novel 3-Dimensional Tissue Phantom Modeling System of the Human Maxilla.
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验证人类上颌骨新型 3 维组织模型建模系统的均匀性。
DOI：
10.1117/12.2654593
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhu,TimothyC
中科院分区：
文献类型：
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作者：
Sourvanos,Dennis;HallMorales,RyanD;Dimofte,Andreea;Fiorellini,JosephP;Zhu,TimothyC
硅体模模型已经被用来计算接受光动力疗法(PDT)治疗的患者的光通量。这一应用也可用于其他非电离波长疗法，如光生物调节(PBM)。我们开发了一种新的协议来验证人类上颌骨的三维硅体模模型的同质性。准确地量化人体组织的光分布可以适应不同受试者之间发生的不同的光学性质。更重要的是，这可以帮助优化光通量剂量计算，以达到预期结果。相同成分的硅模型被制作成两种不同的形状：1平面圆柱形模型，2)非平面(3维)人体上颌模型。制造均匀的硅体模模型仍然是一个挑战，因为微泡在固化过程中会污染化合物。集成了专有的CBCT和手持表面采集成像设备，证实了我们的结果精度在0.5 mm以内。该协议专门用于交叉参考和验证不同渗透深度的同质性。这些结果首次成功验证了具有平面表面和非平面3D平面的相同硅组织体模。这种概念验证体模验证协议对三维表面的特定变化很敏感，可以应用于用于在临床环境中捕获准确光通量计算的工作流程。
Silicon phantom models have been utilized to calculate light fluence in patients being treated with Photodynamic Therapy (PDT). This application can be utilized for other non-ionizing wavelength therapies such as Photobiomodulation (PBM). We have developed a novel protocol to validate homogeneity for 3-dimensional silicon phantom models of the human maxilla. Accurately quantifying the light profiles of human tissue can accommodate for varying optical properties that occur between subjects. More importantly, this can help optimize light fluence dosimetry calculations to achieve intended results. Silicon models of identical composition were fabricated into two different shapes: 1 flat-planar cylindrical shaped model, 2) non-flat planar (3-dimensional) mold of the human maxilla.Fabricating homogenous silicon phantom models continues to be a challenge as micro-bubbles can contaminate the compound during the curing process. Integrating both proprietary CBCT and handheld surface acquisition imaging devices confirmed our results to be within 0.5mm of accuracy. This protocol was specifically used to cross-reference and validate homogeneity at various depths of penetration. These results present the first known successful validation of identical silicon tissue phantoms with a flat-planar surface vs. a non-flat 3D planar surface. This proof-of-concept phantom validation protocol is sensitive to the specific variations of 3-dimensional surfaces and can be applied to a workflow used to capture accurate light fluence calculations in the clinical setting.