Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy.
Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy.
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DOI：
10.1007/978-1-0716-2014-4_12
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发表时间：
2022
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对于非侵入性替代标记物的需求尚未得到满足，这些标记物可以帮助识别不同肿瘤类型的癌前病变。在这里，我们描述的方法和技术细节的协议，在体内13 C丙酮酸代谢成像实验。所描述的方法的目标是识别和理解代谢变化，从而能够检测胰腺癌前病变，作为这种成像方式的高灵敏度的概念的证明。
There is an unmet need for noninvasive surrogate markers that can help identify premalignant lesions across different tumor types. Here we describe the methodology and technical details of protocols employed for in vivo 13C pyruvate metabolic imaging experiments. The goal of the method described is to identify and understand metabolic changes, to enable detection of pancreatic premalignant lesions, as a proof of concept of the high sensitivity of this imaging modality.